D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications

Julien Favresse, Giuseppe Lippi, Pierre-Marie Roy, Bernard Chatelain, Hugues Jacqmin, Hugo ten Cate, Francois Mullier*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

62 Citations (Web of Science)

Abstract

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the optimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE. This review is aimed at (1) revising the definition of D-dimer; (2) discussing preanalytical variables affecting the measurement of D-dimer; (3) reviewing and comparing assay performance and some postanalytical variables (e.g. different units and age-adjusted cutoffs); and (4) discussing the use of D-dimer measurement across different clinical settings.
Original languageEnglish
Pages (from-to)548-577
Number of pages30
JournalCritical Reviews in Clinical Laboratory Sciences
Volume55
Issue number8
DOIs
Publication statusPublished - 17 Nov 2018

Keywords

  • D-dimer
  • preanalytical
  • analytical
  • postanalytical
  • venous thromboembolism
  • DEEP-VEIN THROMBOSIS
  • QUANTITATIVE D-DIMER
  • SUSPECTED VENOUS THROMBOEMBOLISM
  • PARTIAL THROMBOPLASTIN TIME
  • ELEVATED D-DIMER
  • EXCLUDING PULMONARY-EMBOLISM
  • ACUTE AORTIC DISSECTION
  • DETECTION RISK SCORE
  • DIRECT MEDICAL COSTS
  • DIAGNOSTIC WORK-UP

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