Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils

Christine Roeder; Tatsiana Kupreichyk; Lothar Gremer; Luisa U. Schaefer; Karunakar R. Pothula; Raimond B. G. Ravelli; Dieter Willbold; Wolfgang Hoyer; Gunnar F. Schroeder

doi:10.1038/s41594-020-0442-4

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils

Christine Roeder, Tatsiana Kupreichyk, Lothar Gremer, Luisa U. Schaefer, Karunakar R. Pothula, Raimond B. G. Ravelli, Dieter Willbold, Wolfgang Hoyer, Gunnar F. Schroeder

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	660-+
Number of pages	18
Journal	Nature Structural and Molecular Biology
Volume	27
Issue number	7
DOIs	https://doi.org/10.1038/s41594-020-0442-4
Publication status	Published - Jul 2020

Keywords

ATOMIC-RESOLUTION STRUCTURE
ALZHEIMERS-DISEASE
S20G MUTATION
HUMAN AMYLIN
DYNAMICS
IAPP
MECHANISM
SYSTEM
GENE
CRYSTALLOGRAPHY

Access to Document

10.1038/s41594-020-0442-4

Cite this

Roeder, Christine ; Kupreichyk, Tatsiana ; Gremer, Lothar ; Schaefer, Luisa U. ; Pothula, Karunakar R. ; Ravelli, Raimond B. G. ; Willbold, Dieter ; Hoyer, Wolfgang ; Schroeder, Gunnar F. / Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils. In: Nature Structural and Molecular Biology. 2020 ; Vol. 27, No. 7. pp. 660-+.

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keywords = "ATOMIC-RESOLUTION STRUCTURE, ALZHEIMERS-DISEASE, S20G MUTATION, HUMAN AMYLIN, DYNAMICS, IAPP, MECHANISM, SYSTEM, GENE, CRYSTALLOGRAPHY",

author = "Christine Roeder and Tatsiana Kupreichyk and Lothar Gremer and Schaefer, {Luisa U.} and Pothula, {Karunakar R.} and Ravelli, {Raimond B. G.} and Dieter Willbold and Wolfgang Hoyer and Schroeder, {Gunnar F.}",

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doi = "10.1038/s41594-020-0442-4",

language = "English",

volume = "27",

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journal = "Nature Structural and Molecular Biology",

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Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils. / Roeder, Christine; Kupreichyk, Tatsiana; Gremer, Lothar; Schaefer, Luisa U.; Pothula, Karunakar R.; Ravelli, Raimond B. G.; Willbold, Dieter; Hoyer, Wolfgang; Schroeder, Gunnar F.

In: Nature Structural and Molecular Biology, Vol. 27, No. 7, 07.2020, p. 660-+.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils

AU - Roeder, Christine

AU - Kupreichyk, Tatsiana

AU - Gremer, Lothar

AU - Schaefer, Luisa U.

AU - Pothula, Karunakar R.

AU - Ravelli, Raimond B. G.

AU - Willbold, Dieter

AU - Hoyer, Wolfgang

AU - Schroeder, Gunnar F.

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KW - ATOMIC-RESOLUTION STRUCTURE

KW - ALZHEIMERS-DISEASE

KW - S20G MUTATION

KW - HUMAN AMYLIN

KW - DYNAMICS

KW - IAPP

KW - MECHANISM

KW - SYSTEM

KW - GENE

KW - CRYSTALLOGRAPHY

U2 - 10.1038/s41594-020-0442-4

DO - 10.1038/s41594-020-0442-4

M3 - Article

C2 - 32541895

VL - 27

SP - 660-+

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

SN - 1545-9993

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