@article{31583badb1ff493e8a3d3276bea92000,
title = "Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis",
abstract = "Supplementation with nicotinamide adenine dinucleotide (NAD(+)) precursors including dietary nicotinamide has been found to boost tissue NAD(+) levels and ameliorate oxidative stress-induced damage that contributes to aging and aging-related diseases. The association between dietary NAD(+) precursors and patient-reported health-related outcomes in cancer survivors has not been investigated. This study aimed to determine associations of dietary nicotinamide intake with different patient-reported outcomes in colorectal cancer survivors, 2 to 10 years post-diagnosis. A total of 145 eligible participants were recruited into this cross-sectional study. Dietary nicotinamide intake level was calculated based on data from 7-day food diaries. Fatigue was assessed with the Checklist Individual Strength (CIS), which is a subscale of the cancer-specific European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC), and anxiety and depression were assessed with Hospital Anxiety and Depression Scale (HADS). Oxidative stress marker serum protein carbonyl contents and serum NAD(+) levels were measured. A hierarchical linear regression model with confounder adjustment was performed to analyze the association of nicotinamide intake, serum protein carbonyl contents, and NAD(+) levels with patient-reported outcomes. The median values of daily nicotinamide intake for male and female participants were 19.1 and 14.4 mg, respectively. Daily dietary nicotinamide intake was associated with a lower level of fatigue (beta: -14.85 (-28.14, -1.56)) and a lower level of anxiety and depression (beta: -4.69 (-8.55, -0.83)). Subgroup analyses by sex showed that a beneficial association between nicotinamide intake and patient-reported outcomes was mainly found in men. To conclude, our findings suggested that higher dietary NAD(+) precursor nicotinamide intake was cross-sectionally associated with less patient-reported outcomes in CRC survivors.",
keywords = "colorectal cancer survivor, fatigue, patient-reported outcomes, nicotinamide, NAD(+) precursor, QUALITY-OF-LIFE, LONG-TERM EVALUATION, B-VITAMINS, ADENINE-DINUCLEOTIDE, DEPRESSIVE SYMPTOMS, INITIAL TREATMENT, SUPPLEMENT USE, FATIGUE, NAD(+), PERFORMANCE",
author = "Wenbo Wu and Martijn Bours and Annaleen Koole and Kenkhuis, {Marlou Floor} and Simone Eussen and St{\'e}phanie Breukink and {van Schooten}, Frederik and Matty Weijenberg and Geja Hageman",
note = "Funding Information: Funding: The EnCoRe study was supported by Kankeronderzoekfonds Limburg as part of the Health Foundation Limburg (grant 00005739), by Stichting Alpe d{\textquoteright}Huzes within the research program “Leven met kanker” of the Dutch Cancer Society grants UM 2010-4867 and UM 2012-5653, and by ERA-NET on Translational Cancer Research (TRANSCAN: Dutch Cancer Society (UM 2014-6877)). M. Kenkhuis is supported by a grant from Wereld KankerOnderzoek Fonds (WKOF)/World Cancer Research Fund International (WCRF) (grant number 2017/1619). W.Wu is supported by China Scholarship Council (CSC) (grant number 201806160187). Funding Information: The EnCoRe study was supported by Kankeronderzoekfonds Limburg as part of the Health Foundation Limburg (grant 00005739), by Stichting Alpe d?Huzes within the research program ?Leven met kanker? of the Dutch Cancer Society grants UM 2010-4867 and UM 2012-5653, and by ERA-NET on Translational Cancer Research (TRANSCAN: Dutch Cancer Society (UM 2014-6877)). M. Kenkhuis is supported by a grant from Wereld KankerOnderzoek Fonds (WKOF)/World Cancer Research Fund International (WCRF) (grant number 2017/1619). W.Wu is supported by China Scholarship Council (CSC) (grant number 201806160187).Acknowledgments: We would like to thank all participants of the EnCoRe study and the health professionals in the three hospitals involved in the recruitment of participants of the study: Maastricht University Medical Centre+, VieCuriMedical Centre, and Zuyderland Medical Centre. We would also like to thank the MEMIC centre for data and information management for facilitating the logistic processes and data management of our study. Finally, we would like to thank the research dietitians and research assistant who are responsible for patient inclusion and follow-up, performing home visits, as well as data collection and processing. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = nov,
doi = "10.3390/nu13113707",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",
}