Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis

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Abstract

Supplementation with nicotinamide adenine dinucleotide (NAD(+)) precursors including dietary nicotinamide has been found to boost tissue NAD(+) levels and ameliorate oxidative stress-induced damage that contributes to aging and aging-related diseases. The association between dietary NAD(+) precursors and patient-reported health-related outcomes in cancer survivors has not been investigated. This study aimed to determine associations of dietary nicotinamide intake with different patient-reported outcomes in colorectal cancer survivors, 2 to 10 years post-diagnosis. A total of 145 eligible participants were recruited into this cross-sectional study. Dietary nicotinamide intake level was calculated based on data from 7-day food diaries. Fatigue was assessed with the Checklist Individual Strength (CIS), which is a subscale of the cancer-specific European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC), and anxiety and depression were assessed with Hospital Anxiety and Depression Scale (HADS). Oxidative stress marker serum protein carbonyl contents and serum NAD(+) levels were measured. A hierarchical linear regression model with confounder adjustment was performed to analyze the association of nicotinamide intake, serum protein carbonyl contents, and NAD(+) levels with patient-reported outcomes. The median values of daily nicotinamide intake for male and female participants were 19.1 and 14.4 mg, respectively. Daily dietary nicotinamide intake was associated with a lower level of fatigue (beta: -14.85 (-28.14, -1.56)) and a lower level of anxiety and depression (beta: -4.69 (-8.55, -0.83)). Subgroup analyses by sex showed that a beneficial association between nicotinamide intake and patient-reported outcomes was mainly found in men. To conclude, our findings suggested that higher dietary NAD(+) precursor nicotinamide intake was cross-sectionally associated with less patient-reported outcomes in CRC survivors.

Original languageEnglish
Article number3707
Number of pages15
JournalNutrients
Volume13
Issue number11
Early online date21 Oct 2021
DOIs
Publication statusPublished - Nov 2021

Keywords

  • colorectal cancer survivor
  • fatigue
  • patient-reported outcomes
  • nicotinamide
  • NAD(+) precursor
  • QUALITY-OF-LIFE
  • LONG-TERM EVALUATION
  • B-VITAMINS
  • ADENINE-DINUCLEOTIDE
  • DEPRESSIVE SYMPTOMS
  • INITIAL TREATMENT
  • SUPPLEMENT USE
  • FATIGUE
  • NAD(+)
  • PERFORMANCE

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