TY - JOUR
T1 - Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)
AU - Tsurkalenko, Olena
AU - Bulaev, Dmitry
AU - O'Sullivan, Marc Paul
AU - Snoeck, Chantal
AU - Ghosh, Soumyabrata
AU - Kolodkin, Alexey
AU - Rommes, Basile
AU - Gawron, Piotr
AU - Moreno, Carlos Vega
AU - Gomes, Clarissa P. C.
AU - Kaysen, Anne
AU - Ohnmacht, Jochen
AU - Schroder, Valerie E.
AU - Pavelka, Lukas
AU - Meyers, Guilherme Ramos
AU - Pauly, Laure
AU - Pauly, Claire
AU - Hanff, Anne-Marie
AU - Meyrath, Max
AU - Leist, Anja
AU - Sandt, Estelle
AU - Aguayo, Gloria A.
AU - Perquin, Magali
AU - Gantenbein, Manon
AU - Abdelrahman, Tamir
AU - Klucken, Jochen
AU - Satagopam, Venkata
AU - Hilger, Christiane
AU - Turner, Jonathan
AU - Vaillant, Michel
AU - Fritz, Joelle V.
AU - Ollert, Markus
AU - Kruger, Rejko
AU - CON VINCE Consortium
AU - ORCHESTRA Working Group
PY - 2024/2/9
Y1 - 2024/2/9
N2 - BackgroundDuring the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.MethodsA representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.ResultsOne thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.ConclusionThe data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.Trial registrationTrial registration number: NCT04379297, 10 April 2020.
AB - BackgroundDuring the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.MethodsA representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.ResultsOne thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.ConclusionThe data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.Trial registrationTrial registration number: NCT04379297, 10 April 2020.
KW - Coronavirus (COVID-19)
KW - SARS-CoV-2
KW - Prospective cohort study
KW - Prevalence
KW - GENERALIZED ANXIETY DISORDER
KW - POPULATION
KW - SCALE
KW - LONELINESS
U2 - 10.1186/s12879-024-09055-z
DO - 10.1186/s12879-024-09055-z
M3 - Article
SN - 1471-2334
VL - 24
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
IS - 1
M1 - 179
ER -