COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

T. Chatzikonstantinou, A. Kapetanakis, L. Scarfo, G. Karakatsoulis, D. Allsup, A.A. Cabrero, M. Andres, D. Antic, M. Baile, P. Baliakas, D. Bron, A. Capasso, S. Chatzileontiadou, R. Cordoba, J.G. Correa, C. Cuellar-Garcia, L. De Paoli, M.R. De Paolis, G. Del Poeta, C. DemosthenousM. Dimou, D. Donaldson, M. Doubek, M. Efstathopoulou, B. Eichhorst, S. El-Ashwah, A. Enrico, B. Espinet, L. Farina, A. Ferrari, M. Foglietta, H. Frederiksen, M. Furstenau, J.A. Garcia-Marco, R. Garcia-Serra, M. Gentile, E. Gimeno, A. Glenthoj, M.G. da Silva, O. Gutwein, Y.K. Hakobyan, Y. Herishanu, J.A. Hernandez-Rivas, T. Herold, I. Innocenti, G. Itchaki, O. Jaksic, A. Janssens, O.B. Kalashnikova, E. Kalicinska, M. van Gelder, Kostas Stamatopoulos*, Paolo Ghia*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Web of Science)


Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
Original languageEnglish
Pages (from-to)3444-3454
Number of pages11
Issue number12
Early online date1 Nov 2021
Publication statusPublished - Dec 2021

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