TY - JOUR
T1 - Correlation between quantitative and semiquantitative parameters in DCE-MRI with a blood pool agent in rectal cancer
T2 - can semiquantitative parameters be used as a surrogate for quantitative parameters?
AU - Dijkhoff, Rebecca A. P.
AU - Maas, Monique
AU - Martens, Milou H.
AU - Papanikolaou, Nikolaos
AU - Lambregts, Doenja M. J.
AU - Beets, Geerard L.
AU - Beets-Tan, Regina G. H.
PY - 2017/5
Y1 - 2017/5
N2 - Purpose: The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting.Materials and methods: Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar (R), Lantheus Medical Imaging, North Billerica, Massachusetts, USA). Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 2.2 software permeability module using the extended Tofts model. Semiquantitative parameters were calculated on a pixel-by-pixel basis. Spearman rank correlation tests were used for assessment of correlation between parameters. A p valueResults: Strong positive correlations were found between mean peak enhancement and mean K-trans: 0.79 (all patients, p <0.0001), 0.83 (primary staging, p = 0.003), and 0.81 (restaging, p = 0.054). Mean wash-in correlated significantly with mean V-p and K-ep (0.79 and 0.58, respectively, p <0.0001 and p = 0.009) in all patients. Mean wash-in showed a significant correlation with mean K-ep (0.67, p = 0.033) in the primary staging group. On the restaging MRI, mean wash-in only strongly correlated with mean V-p (0.81, p - 0.054).Conclusion: This study shows a strong correlation between quantitative and semiquantitative parameters in DCE-MRI for rectal cancer. Peak enhancement correlates strongly with K-trans and wash-in showed strong correlation with V-p and K-ep. These parameters have been reported to predict tumor aggressiveness and response in rectal cancer. Therefore, semiquantitative analyses might be a surrogate for quantitative analyses.
AB - Purpose: The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting.Materials and methods: Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar (R), Lantheus Medical Imaging, North Billerica, Massachusetts, USA). Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 2.2 software permeability module using the extended Tofts model. Semiquantitative parameters were calculated on a pixel-by-pixel basis. Spearman rank correlation tests were used for assessment of correlation between parameters. A p valueResults: Strong positive correlations were found between mean peak enhancement and mean K-trans: 0.79 (all patients, p <0.0001), 0.83 (primary staging, p = 0.003), and 0.81 (restaging, p = 0.054). Mean wash-in correlated significantly with mean V-p and K-ep (0.79 and 0.58, respectively, p <0.0001 and p = 0.009) in all patients. Mean wash-in showed a significant correlation with mean K-ep (0.67, p = 0.033) in the primary staging group. On the restaging MRI, mean wash-in only strongly correlated with mean V-p (0.81, p - 0.054).Conclusion: This study shows a strong correlation between quantitative and semiquantitative parameters in DCE-MRI for rectal cancer. Peak enhancement correlates strongly with K-trans and wash-in showed strong correlation with V-p and K-ep. These parameters have been reported to predict tumor aggressiveness and response in rectal cancer. Therefore, semiquantitative analyses might be a surrogate for quantitative analyses.
KW - Rectal cancer
KW - Dynamic contrast-enhanced MRI
KW - Correlation
KW - Semiquantitative
KW - Quantitative
KW - CONTRAST-ENHANCED MRI
KW - SIGNAL INTENSITY-TIME
KW - NEOADJUVANT CHEMORADIATION
KW - BREAST
KW - TUMOR
KW - LESIONS
KW - ANGIOGENESIS
KW - THERAPY
KW - CURVES
KW - CARCINOMA
U2 - 10.1007/s00261-016-1024-0
DO - 10.1007/s00261-016-1024-0
M3 - Article
C2 - 28050622
SN - 2366-004X
VL - 42
SP - 1342
EP - 1349
JO - Abdominal Radiology
JF - Abdominal Radiology
IS - 5
ER -