Correlation between quantitative and semiquantitative parameters in DCE-MRI with a blood pool agent in rectal cancer: can semiquantitative parameters be used as a surrogate for quantitative parameters?

Rebecca A. P. Dijkhoff, Monique Maas*, Milou H. Martens, Nikolaos Papanikolaou, Doenja M. J. Lambregts, Geerard L. Beets, Regina G. H. Beets-Tan

*Corresponding author for this work

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Abstract

Purpose: The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting.

Materials and methods: Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar (R), Lantheus Medical Imaging, North Billerica, Massachusetts, USA). Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 2.2 software permeability module using the extended Tofts model. Semiquantitative parameters were calculated on a pixel-by-pixel basis. Spearman rank correlation tests were used for assessment of correlation between parameters. A p value

Results: Strong positive correlations were found between mean peak enhancement and mean K-trans: 0.79 (all patients, p <0.0001), 0.83 (primary staging, p = 0.003), and 0.81 (restaging, p = 0.054). Mean wash-in correlated significantly with mean V-p and K-ep (0.79 and 0.58, respectively, p <0.0001 and p = 0.009) in all patients. Mean wash-in showed a significant correlation with mean K-ep (0.67, p = 0.033) in the primary staging group. On the restaging MRI, mean wash-in only strongly correlated with mean V-p (0.81, p - 0.054).

Conclusion: This study shows a strong correlation between quantitative and semiquantitative parameters in DCE-MRI for rectal cancer. Peak enhancement correlates strongly with K-trans and wash-in showed strong correlation with V-p and K-ep. These parameters have been reported to predict tumor aggressiveness and response in rectal cancer. Therefore, semiquantitative analyses might be a surrogate for quantitative analyses.

Original languageEnglish
Pages (from-to)1342-1349
Number of pages8
JournalAbdominal Radiology
Volume42
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Rectal cancer
  • Dynamic contrast-enhanced MRI
  • Correlation
  • Semiquantitative
  • Quantitative
  • CONTRAST-ENHANCED MRI
  • SIGNAL INTENSITY-TIME
  • NEOADJUVANT CHEMORADIATION
  • BREAST
  • TUMOR
  • LESIONS
  • ANGIOGENESIS
  • THERAPY
  • CURVES
  • CARCINOMA

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