Concurrent frontal and parietal network TMS for modulating attention

S. Gallotto*, T. Schuhmann, F. Duecker, M. Middag-van Spanje, T.A. de Graaf, A.T. Sack

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Transcranial magnetic stimulation (TMS) has been applied to frontal eye field (FEF) and intraparietal sulcus (IPS) in isolation, to study their role in attention. However, these nodes closely interact in a "dorsal attention network''. Here, we compared effects of inhibitory TMS applied to individually fMRI-localized FEF or IPS (single-node TMS), to effects of simultaneously inhibiting both regions ("network TMS''), and sham. We assessed attention performance using the lateralized attention network test, which captures multiple facets of attention: spatial orienting, alerting, and executive control. TMS showed no effects on alerting and executive control. For spatial orienting, only network TMS showed a reduction of the orienting effect in the right hemifield compared to the left hemifield, irrespective of the order of TMS application (IPS -> FEF or FEF -> IPS). Network TMS might prevent compensatory mechanisms within a brain network, which is promising for both research and clinical applications to achieve superior neuromodulation effects
Original languageEnglish
Article number103962
Number of pages15
JournaliScience
Volume25
Issue number3
DOIs
Publication statusPublished - 18 Mar 2022

Keywords

  • TRANSCRANIAL MAGNETIC STIMULATION
  • THETA-BURST STIMULATION
  • HUMAN VISUAL-CORTEX
  • SPATIAL ATTENTION
  • HEMISPHERIC-DIFFERENCES
  • DIRECTED ATTENTION
  • CAUSAL INFLUENCES
  • EYE FIELD
  • NEGLECT
  • MOTOR

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