COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER

Roel G. J. Kierkels; Walter H. Backes; Marco H. M. Janssen; Jeroen Buijsen; Regina G. H. Beets-Tan; Philippe Lambin; Guido Lammerng; Michel C. Oellers; Hugo J. W. L. Aerts

doi:10.1016/j.ijrobp.2009.05.015

COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER

Roel G. J. Kierkels, Walter H. Backes, Marco H. M. Janssen, Jeroen Buijsen, Regina G. H. Beets-Tan, Philippe Lambin, Guido Lammerng, Michel C. Oellers, Hugo J. W. L. Aerts^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p

Original language	English
Pages (from-to)	400-408
Journal	International Journal of Radiation Oncology Biology Physics
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.ijrobp.2009.05.015
Publication status	Published - 1 Jun 2010

Keywords

Perfusion CT
DCE-MRI
Pharmacokinetic model
Rectal cancer
Tumor perfusion

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10.1016/j.ijrobp.2009.05.015

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Cite this

Kierkels, R. G. J., Backes, W. H., Janssen, M. H. M., Buijsen, J., Beets-Tan, R. G. H., Lambin, P., Lammerng, G., Oellers, M. C., & Aerts, H. J. W. L. (2010). COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER. International Journal of Radiation Oncology Biology Physics, 77(2), 400-408. https://doi.org/10.1016/j.ijrobp.2009.05.015

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title = "COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER",

abstract = "Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p ",

keywords = "Perfusion CT, DCE-MRI, Pharmacokinetic model, Rectal cancer, Tumor perfusion",

author = "Kierkels, {Roel G. J.} and Backes, {Walter H.} and Janssen, {Marco H. M.} and Jeroen Buijsen and Beets-Tan, {Regina G. H.} and Philippe Lambin and Guido Lammerng and Oellers, {Michel C.} and Aerts, {Hugo J. W. L.}",

year = "2010",

month = jun,

day = "1",

doi = "10.1016/j.ijrobp.2009.05.015",

language = "English",

volume = "77",

pages = "400--408",

journal = "International Journal of Radiation Oncology Biology Physics",

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Kierkels, RGJ, Backes, WH, Janssen, MHM, Buijsen, J , Beets-Tan, RGH , Lambin, P, Lammerng, G, Oellers, MC & Aerts, HJWL 2010, 'COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER', International Journal of Radiation Oncology Biology Physics, vol. 77, no. 2, pp. 400-408. https://doi.org/10.1016/j.ijrobp.2009.05.015

COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER. / Kierkels, Roel G. J.; Backes, Walter H.; Janssen, Marco H. M. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 77, No. 2, 01.06.2010, p. 400-408.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER

AU - Kierkels, Roel G. J.

AU - Backes, Walter H.

AU - Janssen, Marco H. M.

AU - Buijsen, Jeroen

AU - Beets-Tan, Regina G. H.

AU - Lambin, Philippe

AU - Lammerng, Guido

AU - Oellers, Michel C.

AU - Aerts, Hugo J. W. L.

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N2 - Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p

AB - Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p

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KW - DCE-MRI

KW - Pharmacokinetic model

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KW - Tumor perfusion

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DO - 10.1016/j.ijrobp.2009.05.015

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SN - 0360-3016

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SP - 400

EP - 408

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 2

ER -