COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER

Roel G. J. Kierkels, Walter H. Backes, Marco H. M. Janssen, Jeroen Buijsen, Regina G. H. Beets-Tan, Philippe Lambin, Guido Lammerng, Michel C. Oellers, Hugo J. W. L. Aerts*

*Corresponding author for this work

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Abstract

Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p
Original languageEnglish
Pages (from-to)400-408
JournalInternational Journal of Radiation Oncology Biology Physics
Volume77
Issue number2
DOIs
Publication statusPublished - 1 Jun 2010

Keywords

  • Perfusion CT
  • DCE-MRI
  • Pharmacokinetic model
  • Rectal cancer
  • Tumor perfusion

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