Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann; Dennis van der Meer; null Nhat Trung Doan; Emanuel Schwarz; Martina J. Lund; Ingrid Agartz; Dag Alnaes; Deanna M. Barch; Ramona Baur-Streubel; Alessandro Bertolino; Francesco Bettella; Mona K. Beyer; Erlend Boen; Stefan Borgwardt; Christine L. Brandt; Jan Buitelaar; Elisabeth G. Celius; Simon Cervenka; Annette Conzelmann; Aldo Cordova-Palomera; Anders M. Dale; Dominique J. F. de Quervain; PasqualeDi Carlo; Srdjan Djurovic; Erlend S. Dorum; Sarah Eisenacher; Torbjorn Elvsashagen; Thomas Espeseth; Helena Fatouros-Bergman; Lena Flyckt; Barbara Franke; Oleksandr Frei; Beathe Haatveit; Asta K. Haberg; Hanne F. Harbo; Catharina A. Hartman; Dirk Heslenfeld; Pieter J. Hoekstra; Einar A. Hogestol; Terry L. Jernigan; Rune Jonassen; Erik G. Jonsson; Peter Kirsch; Iwona Ktoszewska; Knut K. Kolskar; Nils Inge Landro; StephanieLe Hellard; Klaus-Peter Lesch; Simon Lovestone; Arvid Lundervold; Karolinska Schizophrenia Project KaSP; Lars T. Westlye

doi:10.1038/s41593-019-0471-7

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann^*, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina J. Lund, Ingrid Agartz, Dag Alnaes, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Francesco Bettella, Mona K. Beyer, Erlend Boen, Stefan Borgwardt, Christine L. Brandt, Jan Buitelaar, Elisabeth G. Celius, Simon Cervenka, Annette Conzelmann, Aldo Cordova-PalomeraAnders M. Dale, Dominique J. F. de Quervain, PasqualeDi Carlo, Srdjan Djurovic, Erlend S. Dorum, Sarah Eisenacher, Torbjorn Elvsashagen, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Beathe Haatveit, Asta K. Haberg, Hanne F. Harbo, Catharina A. Hartman, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Hogestol, Terry L. Jernigan, Rune Jonassen, Erik G. Jonsson, Peter Kirsch, Iwona Ktoszewska, Knut K. Kolskar, Nils Inge Landro, StephanieLe Hellard, Klaus-Peter Lesch, Simon Lovestone, Arvid Lundervold, Karolinska Schizophrenia Project KaSP, Lars T. Westlye^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Original language	English
Pages (from-to)	1617-1623
Number of pages	9
Journal	Nature Neuroscience
Volume	22
Issue number	10
DOIs	https://doi.org/10.1038/s41593-019-0471-7
Publication status	Published - Oct 2019

Keywords

MULTIPLE-SCLEROSIS
AGE
SCHIZOPHRENIA
ALZHEIMERS
LOCI
MRI

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1 Erratum / corrigendum / retractions

Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain: Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Bøen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A. & Córdova-Palomera, A. & 31 others, Dale, A. M., de Quervain, D. J. F., Di Carlo, P., Djurovic, S., Dørum, E. S., Eisenacher, S., Elvsåshagen, T., Espeseth, T., Fatouros-Bergman, H., Flyckt, L., Franke, B., Frei, O., Haatveit, B., Håberg, A. K., Harbo, H. F., Hartman, C. A., Heslenfeld, D., Hoekstra, P. J., Høgestøl, E. A., Jernigan, T. L., Jonassen, R., Jönsson, E. G., Kirsch, P., Kłoszewska, I., Kolskår, K. K., Landrø, N. I., Le Hellard, S., Lesch, K.-P., Lovestone, S., Lundervold, A. & Karolinska Schizophrenia Project KaSP, Feb 2020, In: Nature Neuroscience. 23, 2, p. 295-295 1 p., 295.
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Open Access

Cite this

Kaufmann, T., van der Meer, D., Nhat Trung Doan, Schwarz, E., Lund, M. J., Agartz, I., Alnaes, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Boen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A., ... Westlye, L. T. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience, 22(10), 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

@article{47baf984600f4d6dab74a8ff2108b8d0,

title = "Common brain disorders are associated with heritable patterns of apparent aging of the brain",

abstract = "Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.",

keywords = "MULTIPLE-SCLEROSIS, AGE, SCHIZOPHRENIA, ALZHEIMERS, LOCI, MRI",

author = "Tobias Kaufmann and {van der Meer}, Dennis and {Nhat Trung Doan} and Emanuel Schwarz and Lund, {Martina J.} and Ingrid Agartz and Dag Alnaes and Barch, {Deanna M.} and Ramona Baur-Streubel and Alessandro Bertolino and Francesco Bettella and Beyer, {Mona K.} and Erlend Boen and Stefan Borgwardt and Brandt, {Christine L.} and Jan Buitelaar and Celius, {Elisabeth G.} and Simon Cervenka and Annette Conzelmann and Aldo Cordova-Palomera and Dale, {Anders M.} and {de Quervain}, {Dominique J. F.} and PasqualeDi Carlo and Srdjan Djurovic and Dorum, {Erlend S.} and Sarah Eisenacher and Torbjorn Elvsashagen and Thomas Espeseth and Helena Fatouros-Bergman and Lena Flyckt and Barbara Franke and Oleksandr Frei and Beathe Haatveit and Haberg, {Asta K.} and Harbo, {Hanne F.} and Hartman, {Catharina A.} and Dirk Heslenfeld and Hoekstra, {Pieter J.} and Hogestol, {Einar A.} and Jernigan, {Terry L.} and Rune Jonassen and Jonsson, {Erik G.} and Peter Kirsch and Iwona Ktoszewska and Kolskar, {Knut K.} and Landro, {Nils Inge} and StephanieLe Hellard and Klaus-Peter Lesch and Simon Lovestone and Arvid Lundervold and {Karolinska Schizophrenia Project KaSP} and Westlye, {Lars T.}",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2019",

month = oct,

doi = "10.1038/s41593-019-0471-7",

language = "English",

volume = "22",

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Kaufmann, T, van der Meer, D, Nhat Trung Doan, Schwarz, E, Lund, MJ, Agartz, I, Alnaes, D, Barch, DM, Baur-Streubel, R, Bertolino, A, Bettella, F, Beyer, MK, Boen, E, Borgwardt, S, Brandt, CL, Buitelaar, J, Celius, EG, Cervenka, S, Conzelmann, A, Cordova-Palomera, A, Dale, AM, de Quervain, DJF, Carlo, P, Djurovic, S, Dorum, ES, Eisenacher, S, Elvsashagen, T, Espeseth, T, Fatouros-Bergman, H, Flyckt, L, Franke, B, Frei, O, Haatveit, B, Haberg, AK, Harbo, HF, Hartman, CA, Heslenfeld, D, Hoekstra, PJ, Hogestol, EA, Jernigan, TL, Jonassen, R, Jonsson, EG, Kirsch, P, Ktoszewska, I, Kolskar, KK, Landro, NI, Hellard, S, Lesch, K-P, Lovestone, S, Lundervold, A, Karolinska Schizophrenia Project KaSP & Westlye, LT 2019, 'Common brain disorders are associated with heritable patterns of apparent aging of the brain', Nature Neuroscience, vol. 22, no. 10, pp. 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

TY - JOUR

T1 - Common brain disorders are associated with heritable patterns of apparent aging of the brain

AU - Kaufmann, Tobias

AU - van der Meer, Dennis

AU - Nhat Trung Doan, null

AU - Schwarz, Emanuel

AU - Lund, Martina J.

AU - Agartz, Ingrid

AU - Alnaes, Dag

AU - Barch, Deanna M.

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bettella, Francesco

AU - Beyer, Mona K.

AU - Boen, Erlend

AU - Borgwardt, Stefan

AU - Brandt, Christine L.

AU - Buitelaar, Jan

AU - Celius, Elisabeth G.

AU - Cervenka, Simon

AU - Conzelmann, Annette

AU - Cordova-Palomera, Aldo

AU - Dale, Anders M.

AU - de Quervain, Dominique J. F.

AU - Carlo, PasqualeDi

AU - Djurovic, Srdjan

AU - Dorum, Erlend S.

AU - Eisenacher, Sarah

AU - Elvsashagen, Torbjorn

AU - Espeseth, Thomas

AU - Fatouros-Bergman, Helena

AU - Flyckt, Lena

AU - Franke, Barbara

AU - Frei, Oleksandr

AU - Haatveit, Beathe

AU - Haberg, Asta K.

AU - Harbo, Hanne F.

AU - Hartman, Catharina A.

AU - Heslenfeld, Dirk

AU - Hoekstra, Pieter J.

AU - Hogestol, Einar A.

AU - Jernigan, Terry L.

AU - Jonassen, Rune

AU - Jonsson, Erik G.

AU - Kirsch, Peter

AU - Ktoszewska, Iwona

AU - Kolskar, Knut K.

AU - Landro, Nils Inge

AU - Hellard, StephanieLe

AU - Lesch, Klaus-Peter

AU - Lovestone, Simon

AU - Lundervold, Arvid

AU - Karolinska Schizophrenia Project KaSP

AU - Westlye, Lars T.

PY - 2019/10

Y1 - 2019/10

N2 - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

AB - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

KW - MULTIPLE-SCLEROSIS

KW - AGE

KW - SCHIZOPHRENIA

KW - ALZHEIMERS

KW - LOCI

KW - MRI

U2 - 10.1038/s41593-019-0471-7

DO - 10.1038/s41593-019-0471-7

M3 - Article

C2 - 31551603

SN - 1097-6256

VL - 22

SP - 1617

EP - 1623

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 10

ER -

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Abstract

Keywords

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Research output

Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain: Common brain disorders are associated with heritable patterns of apparent aging of the brain

Cite this