Background: As depression is a considerable risk factor for an unfa- University of Maastricht, The Netherlands vourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue. Objective: The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression. Methods: Cognitive performance of 54 depressed patients post first-MI treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test. Results: The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance. Conclusion: In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.
Strik, J. J. M. H., Honig, A., Klinkenberg, E. L., Dijkstra, J., & Jolles, J. (2006). Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction. Acta Neuropsychiatrica, 18, 1-2007. https://doi.org/10.1111/j.0924-2708.2006.00110.x