Cluster analysis for repeated data with dropout: Sensitivity analysis using a distal event

Liesbeth Bruckers*, Geert Molenberghs, Bianca Pulinx, Femina Hellenthal, Geert Schurink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Degeneration of the aortic wall becomes life-threatening when the risk of rupture increases. Cluster analysis on repeated measures of the diameter of the artery revealed two subgroups of patients included in a surveillance program. These results were obtained under the assumption of missingness at random. In this article, we study the vulnerability of the cluster analysis results - the estimated trajectories and the posterior membership probabilities - by applying different missing-data models for non-ignorable dropout, as proposed by Muthen et al. (2011) to the growth of the diameter of the artery.
Original languageEnglish
Pages (from-to)983-1004
Number of pages22
JournalJournal of Biopharmaceutical Statistics
Volume28
Issue number5
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Distal event
  • incomplete data
  • latent-class growth models
  • pattern-mixture models
  • selection models
  • sensitivity analysis
  • PATTERN-MIXTURE MODELS
  • INCOMPLETE DATA
  • LONGITUDINAL DATA
  • MISSING DATA
  • EM ALGORITHM
  • LIKELIHOOD
  • FIT

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