Abstract
Background/Aim: To determine the clinical significance of pre-treatment circumferential tumor location within the esophageal wall in patients with locally advanced esophageal squamous cell carcinoma who underwent curative resection after neoadjuvant chemotherapy. Patients and Methods: Patients (n=96) with cStage IB-III esophageal squamous cell carcinoma who underwent curative resection after neoadjuvant chemotherapy were categorized into two groups based on the circumferential tumor location within the esophageal wall on diagnostic endoscopy: left or anterior wall group (L/A patients, n=49); right or posterior wall group (R/P patients, n=47). Analyses were conducted to examine the relationship between circumferential tumor location, clinicopathological characteristics, 3-year overall survival (3Y-OS), and 3-year recurrence-free survival (3Y-RFS). Results: The lymph node status and recurrence rates of mediastinal lymph node metastases were significantly higher in patients with L/A than in patients with R/P. Furthermore, patients with L/A had significantly poorer 3Y -OS and 3Y-RFS than those with R/P. Tumor location within the esophageal wall was identified in multivariate analysis as an independent risk factor for 3Y-RFS (hazard ratio=2.92, 95% confidence interval=1.35-6.32, p=0.0064). Conclusion: Pre-treatment of circumferential tumor located within the esophageal wall may be a useful prognostic factor in patients with cStageIB-III esophageal squamous cell carcinoma who underwent curative resection after neoadjuvant chemotherapy.
Original language | English |
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Pages (from-to) | 2697-2705 |
Number of pages | 9 |
Journal | Anticancer Research |
Volume | 43 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2023 |
Keywords
- Esophageal squamous cell cancer
- tumor location
- neoadjuvant chemotherapy
- prognostic factor
- DIRECT LYMPHATIC DRAINAGE
- ESOPHAGOGASTRIC JUNCTION
- CHEMOTHERAPY
- CARCINOMA
- RECURRENCE
- DOCETAXEL
- SURVIVAL
- SURGERY
- ANATOMY
- IMPACT