TY - JOUR
T1 - Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
T2 - a prospective cohort study
AU - Habib, Gilbert
AU - Erba, Paola Anna
AU - Iung, Bernard
AU - Donal, Erwan
AU - Cosyns, Bernard
AU - Laroche, Cecile
AU - Popescu, Bogdan A.
AU - Prendergast, Bernard
AU - Tornos, Pilar
AU - Sadeghpour, Anita
AU - Oliver, Leopold
AU - Vaskelyte, Jolanta-Justina
AU - Sow, Rouguiatou
AU - Axler, Olivier
AU - Maggioni, Aldo P.
AU - Lancellotti, Patrizio
AU - Granada, null
AU - Mahia, M.
AU - Ressi, S.
AU - Nacinovich, F.
AU - Iribarren, A.
AU - Fernandez Oses, P.
AU - Avegliano, G.
AU - Filipini, E.
AU - Obregon, R.
AU - Bangher, M.
AU - Dho, J.
AU - Cartasegna, L.
AU - Plastino, M. L.
AU - Novas, null
AU - Shigel, C.
AU - Reyes, G.
AU - Schneider, M.
AU - Ahmed, M.
AU - Ali, M.
AU - Landry, G.
AU - Wild, C.
AU - Papadopoulos, C.
AU - Crijns, H. J.
AU - Bekkers, S. C.
AU - Cheriex, E. C.
AU - Gilbers, M.
AU - Kietselaer, B. L.
AU - Knackstedt, C.
AU - Lorusso, R.
AU - Schalla, S.
AU - Streukens, S. A.
AU - van Dongen, E.
AU - Ahmed, B.
AU - Ahmed, A.
AU - EURO-ENDO Investigators
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/10/14
Y1 - 2019/10/14
N2 - Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE).Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). F-18-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated.Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
AB - Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE).Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). F-18-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated.Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
KW - Infective endocarditis
KW - Registry
KW - Valve disease
KW - EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY
KW - MANAGEMENT
KW - DIAGNOSIS
KW - SURGERY
KW - ECHOCARDIOGRAPHY
U2 - 10.1093/eurheartj/ehz620
DO - 10.1093/eurheartj/ehz620
M3 - Article
C2 - 31504413
SN - 0195-668X
VL - 40
SP - 3222-3232B
JO - European Heart Journal
JF - European Heart Journal
IS - 39
ER -