Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection

Ying Hou, Gretchen Hermann, John H. Lewis, Hugo J. Aerts, Elizabeth H. Baldini, Aileen B. Chen, Yolonda L. Colson, Fred L. Hacker, Joseph H. Killoran, David E. Kozono, Matthew Wagar, Jon O. Wee, Raymond H. Mak*

*Corresponding author for this work

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Abstract

Objectives: Tumor control (TC), toxicity and survival, following stereotactic body radiation therapy (SBRT) were compared between patients with and without a prior lung resection (PLR). Materials and Methods: The study is comprised of 130 patients with 141 peripheral tumors treated with SBRT at our institution from 2009 to 2013. Primary TC and lobar control (LC) were defined per RTOG 0236. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Survival/TC and toxicity were compared between patients with and without PLR using the Kaplan-Meier method and cumulative incidence, respectively. Fine and Gray regression was used for univariable/multivariable analysis for radiation pneumonitis (RP). Results: Of the 130 patients with median age 70 years (range, 42 to 93 y), 50 had undergone PLR (median time between PLR and SBRT: 33 mo; range, 1 to 206), including pneumonectomy (12%), lobectomy (46%), wedge resection (42%). With a median follow-up of 21 months in survivors, the PLR group had better TC (1-y 100% vs. 93%; P<0.01) and increased grade >= 2(RP; 1-y 12% vs. 1%; P<0.01). OS was not significantly different between the 2 groups (1-y 91% vs. 85%; P = 0.24). On univariable/multivariable analyses, biologically effective dose was associated with TC (hazard ratios, 0.97; 95% confidence interval, 0.94-0.999, P = 0.04). Chemotherapy use was associated with grade >= 2 RP for all patients (hazard ratios, 14.92, 95% confidence interval, 5.68-39 21, P<0.0001) in multivariate analysis. PLR was not associated with increased RP in multivariable analysis. Conclusions: Patients with PLR who receive lung SBRT for lung tumors have high local control and relatively low toxicity. SBRT is an excellent option to treat second lung tumors or pulmonary metastases in patients with PLR.
Original languageEnglish
Pages (from-to)695-701
Number of pages7
JournalAmerican Journal of Clinical Oncology-Cancer Clinical Trials
Volume41
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • stereotactic body radiation therapy
  • lung cancer
  • prior lung resection
  • clinical outcomes
  • radiation pneumonitis
  • ABLATIVE RADIOTHERAPY
  • PHASE-II
  • CANCER
  • PNEUMONITIS
  • POSTPNEUMONECTOMY
  • SURVEILLANCE
  • RECURRENCE
  • PATTERNS
  • TUMORS

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