TY - JOUR
T1 - Clinical, electrocardiographic, and electrophysiologic characteristics of patients with a fasciculoventricular pathway: The role of PRKAG2 mutation
AU - Sternick, Eduardo Back
AU - Oliva, Antonio
AU - Gerken, Luiz Marcio
AU - Magalhaes, Luiz
AU - Scarpelli, Ricardo
AU - Correia, Frederico Soares
AU - Rego, Silvia
AU - Santana, Oto
AU - Brugada, Ramon
AU - Wellens, Hein J. J.
PY - 2011/1
Y1 - 2011/1
N2 - BACKGROUND The ECG, clinical, and electrophysiologic profiles of patients with a fasciculoventricular pathway are well described. Fasciculoventricular pathways occurring in the setting of glycogen storage cardiomyopathy possess unique features. OBJECTIVE The purpose of this study was to compare the clinical, ECG, and electrophysiologic characteristics of patients with a fasciculoventricular pathway, with or without glycogen storage cardiomyopathy. METHODS Two groups of patients with a fasciculoventricular pathway were compared: group A consisted of 10 patients with the PRKAG2 mutation (Arg302gln), and group B consisted of 9 patients without the mutation. RESULTS Thirty percent of group A patients had left ventricular hypertrophy, and none had an additional accessory pathway. Group B patients had no structural heart disease, and 33% had an additional accessory pathway. Group A patients had a slower resting heart rate (56 +/- 7 vs 75 +/- 10 bpm, P
AB - BACKGROUND The ECG, clinical, and electrophysiologic profiles of patients with a fasciculoventricular pathway are well described. Fasciculoventricular pathways occurring in the setting of glycogen storage cardiomyopathy possess unique features. OBJECTIVE The purpose of this study was to compare the clinical, ECG, and electrophysiologic characteristics of patients with a fasciculoventricular pathway, with or without glycogen storage cardiomyopathy. METHODS Two groups of patients with a fasciculoventricular pathway were compared: group A consisted of 10 patients with the PRKAG2 mutation (Arg302gln), and group B consisted of 9 patients without the mutation. RESULTS Thirty percent of group A patients had left ventricular hypertrophy, and none had an additional accessory pathway. Group B patients had no structural heart disease, and 33% had an additional accessory pathway. Group A patients had a slower resting heart rate (56 +/- 7 vs 75 +/- 10 bpm, P
KW - Accessory atrioventricular pathway
KW - Atrial fibrillation
KW - Atrial flutter
KW - Atrioventricular block
KW - Fasciculoventricular pathway
KW - Glycogen storage cardiomyopathy
KW - PRKAG2 mutation
KW - Wolff-Parkinson-White syndrome
U2 - 10.1016/j.hrthm.2010.09.081
DO - 10.1016/j.hrthm.2010.09.081
M3 - Article
C2 - 20888928
SN - 1547-5271
VL - 8
SP - 58
EP - 64
JO - Heart Rhythm
JF - Heart Rhythm
IS - 1
ER -