Clinical, electrocardiographic, and electrophysiologic characteristics of patients with a fasciculoventricular pathway: The role of PRKAG2 mutation

Eduardo Back Sternick*, Antonio Oliva, Luiz Marcio Gerken, Luiz Magalhaes, Ricardo Scarpelli, Frederico Soares Correia, Silvia Rego, Oto Santana, Ramon Brugada, Hein J. J. Wellens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

BACKGROUND The ECG, clinical, and electrophysiologic profiles of patients with a fasciculoventricular pathway are well described. Fasciculoventricular pathways occurring in the setting of glycogen storage cardiomyopathy possess unique features. OBJECTIVE The purpose of this study was to compare the clinical, ECG, and electrophysiologic characteristics of patients with a fasciculoventricular pathway, with or without glycogen storage cardiomyopathy. METHODS Two groups of patients with a fasciculoventricular pathway were compared: group A consisted of 10 patients with the PRKAG2 mutation (Arg302gln), and group B consisted of 9 patients without the mutation. RESULTS Thirty percent of group A patients had left ventricular hypertrophy, and none had an additional accessory pathway. Group B patients had no structural heart disease, and 33% had an additional accessory pathway. Group A patients had a slower resting heart rate (56 +/- 7 vs 75 +/- 10 bpm, P
Original languageEnglish
Pages (from-to)58-64
JournalHeart Rhythm
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Accessory atrioventricular pathway
  • Atrial fibrillation
  • Atrial flutter
  • Atrioventricular block
  • Fasciculoventricular pathway
  • Glycogen storage cardiomyopathy
  • PRKAG2 mutation
  • Wolff-Parkinson-White syndrome

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