TY - JOUR
T1 - Clinical assessment of aortic valve stenosis
T2 - Comparison between 4D flow MRI and transthoracic echocardiography
AU - Adriaans, Bouke P.
AU - Westenberg, Jos J. M.
AU - van Cauteren, Yvonne J. M.
AU - Gerretsen, Suzanne
AU - Elbaz, Mohammed S. M.
AU - Bekkers, Sebastiaan C. A. M.
AU - Veenstra, Leo F.
AU - Crijns, Harry J. G. M.
AU - Wildberger, Joachim E.
AU - Schalla, Simon
N1 - Funding Information:
Contract grant sponsor: Stichting de Weijerhorst, Maastricht, Limburg, the Netherlands.
Publisher Copyright:
© 2019 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
PY - 2020/2
Y1 - 2020/2
N2 - Background The prevalence of valvular aortic stenosis (AS) increases as the population ages. Echocardiographic measurements of peak jet velocity (V-peak), mean pressure gradient (P-mean), and aortic valve area (AVA) determine AS severity and play a pivotal role in the stratification towards valvular replacement. A multimodality imaging approach might be needed in cases of uncertainty about the actual severity of the stenosis. Purpose To compare four-dimensional phase-contrast magnetic resonance (4D PC-MR), two-dimensional (2D) PC-MR, and transthoracic echocardiography (TTE) for quantification of AS. Study Type Prospective. Population Twenty patients with various degrees of AS (69.3 +/- 5.0 years). Field Strength/Sequences 4D PC-MR and 2D PC-MR at 3T. Assessment We compared V-peak, P-mean, and AVA between TTE, 4D PC-MR, and 2D PC-MR. Flow eccentricity was quantified by means of normalized flow displacement, and its influence on the accuracy of TTE measurements was investigated. Statistical Tests Pearson's correlation, Bland-Altman analysis, paired t-test, and intraclass correlation coefficient. Results 4D PC-MR measured higher V-peak (r = 0.95, mean difference + 16.4 +/- 10.7%, P
AB - Background The prevalence of valvular aortic stenosis (AS) increases as the population ages. Echocardiographic measurements of peak jet velocity (V-peak), mean pressure gradient (P-mean), and aortic valve area (AVA) determine AS severity and play a pivotal role in the stratification towards valvular replacement. A multimodality imaging approach might be needed in cases of uncertainty about the actual severity of the stenosis. Purpose To compare four-dimensional phase-contrast magnetic resonance (4D PC-MR), two-dimensional (2D) PC-MR, and transthoracic echocardiography (TTE) for quantification of AS. Study Type Prospective. Population Twenty patients with various degrees of AS (69.3 +/- 5.0 years). Field Strength/Sequences 4D PC-MR and 2D PC-MR at 3T. Assessment We compared V-peak, P-mean, and AVA between TTE, 4D PC-MR, and 2D PC-MR. Flow eccentricity was quantified by means of normalized flow displacement, and its influence on the accuracy of TTE measurements was investigated. Statistical Tests Pearson's correlation, Bland-Altman analysis, paired t-test, and intraclass correlation coefficient. Results 4D PC-MR measured higher V-peak (r = 0.95, mean difference + 16.4 +/- 10.7%, P
KW - 4D flow MRI
KW - AREA
KW - EJECTION FRACTION
KW - EUROPEAN ASSOCIATION
KW - FREQUENCY
KW - MAGNETIC-RESONANCE
KW - PARAMETERS
KW - PREDICTORS
KW - QUANTIFICATION
KW - REPLACEMENT
KW - VELOCITY
KW - aortic stenosis
KW - transthoracic echocardiography
KW - valvular heart disease
KW - VALVULAR HEART-DISEASE
U2 - 10.1002/jmri.26847
DO - 10.1002/jmri.26847
M3 - Article
C2 - 31257647
SN - 1053-1807
VL - 51
SP - 472
EP - 480
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 2
ER -