Clinical assessment of aortic valve stenosis: Comparison between 4D flow MRI and transthoracic echocardiography

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Abstract

Background The prevalence of valvular aortic stenosis (AS) increases as the population ages. Echocardiographic measurements of peak jet velocity (V-peak), mean pressure gradient (P-mean), and aortic valve area (AVA) determine AS severity and play a pivotal role in the stratification towards valvular replacement. A multimodality imaging approach might be needed in cases of uncertainty about the actual severity of the stenosis. Purpose To compare four-dimensional phase-contrast magnetic resonance (4D PC-MR), two-dimensional (2D) PC-MR, and transthoracic echocardiography (TTE) for quantification of AS. Study Type Prospective. Population Twenty patients with various degrees of AS (69.3 +/- 5.0 years). Field Strength/Sequences 4D PC-MR and 2D PC-MR at 3T. Assessment We compared V-peak, P-mean, and AVA between TTE, 4D PC-MR, and 2D PC-MR. Flow eccentricity was quantified by means of normalized flow displacement, and its influence on the accuracy of TTE measurements was investigated. Statistical Tests Pearson's correlation, Bland-Altman analysis, paired t-test, and intraclass correlation coefficient. Results 4D PC-MR measured higher V-peak (r = 0.95, mean difference + 16.4 +/- 10.7%, P

Original languageEnglish
Pages (from-to)472-480
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume51
Issue number2
Early online date30 Jun 2019
DOIs
Publication statusPublished - Feb 2020

Keywords

  • 4D flow MRI
  • AREA
  • EJECTION FRACTION
  • EUROPEAN ASSOCIATION
  • FREQUENCY
  • MAGNETIC-RESONANCE
  • PARAMETERS
  • PREDICTORS
  • QUANTIFICATION
  • REPLACEMENT
  • VELOCITY
  • aortic stenosis
  • transthoracic echocardiography
  • valvular heart disease
  • VALVULAR HEART-DISEASE

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