Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

Roberto A. Rabinovich; Bruce E. Miller; Karolina Wrobel; Kareshma Ranjit; Michelle C. Williams; Ellen Drost; Lisa D. Edwards; David A. Lomas; Stephen I. Rennard; Alvar Agusti; Ruth Tal-Singer; Jorgen Vestbo; Emiel F. M. Wouters; Michelle John; Edwin J. R. van Beek; John T. Murchison; Charlotte E. Bolton; William MacNee; Jeffrey T. J. Huang

doi:10.1183/13993003.01824-2015

Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

Roberto A. Rabinovich^*, Bruce E. Miller, Karolina Wrobel, Kareshma Ranjit, Michelle C. Williams, Ellen Drost, Lisa D. Edwards, David A. Lomas, Stephen I. Rennard, Alvar Agusti, Ruth Tal-Singer, Jorgen Vestbo, Emiel F. M. Wouters, Michelle John, Edwin J. R. van Beek, John T. Murchison, Charlotte E. Bolton, William MacNee, Jeffrey T. J. Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic-femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (p

Original language	English
Pages (from-to)	1365-1373
Journal	European Respiratory Journal
Volume	47
Issue number	5
DOIs	https://doi.org/10.1183/13993003.01824-2015
Publication status	Published - May 2016

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10.1183/13993003.01824-2015

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Rabinovich, R. A., Miller, B. E., Wrobel, K., Ranjit, K., Williams, M. C., Drost, E., Edwards, L. D., Lomas, D. A., Rennard, S. I., Agusti, A., Tal-Singer, R., Vestbo, J., Wouters, E. F. M., John, M., van Beek, E. J. R., Murchison, J. T., Bolton, C. E., MacNee, W., & Huang, J. T. J. (2016). Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. European Respiratory Journal, 47(5), 1365-1373. https://doi.org/10.1183/13993003.01824-2015

@article{e2387ad0af4d462c8e6f945ade373aad,

title = "Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD",

abstract = "Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic-femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (p",

author = "Rabinovich, {Roberto A.} and Miller, {Bruce E.} and Karolina Wrobel and Kareshma Ranjit and Williams, {Michelle C.} and Ellen Drost and Edwards, {Lisa D.} and Lomas, {David A.} and Rennard, {Stephen I.} and Alvar Agusti and Ruth Tal-Singer and Jorgen Vestbo and Wouters, {Emiel F. M.} and Michelle John and {van Beek}, {Edwin J. R.} and Murchison, {John T.} and Bolton, {Charlotte E.} and William MacNee and Huang, {Jeffrey T. J.}",

year = "2016",

month = may,

doi = "10.1183/13993003.01824-2015",

language = "English",

volume = "47",

pages = "1365--1373",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "5",

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Rabinovich, RA, Miller, BE, Wrobel, K, Ranjit, K, Williams, MC, Drost, E, Edwards, LD, Lomas, DA, Rennard, SI, Agusti, A, Tal-Singer, R, Vestbo, J, Wouters, EFM, John, M, van Beek, EJR, Murchison, JT, Bolton, CE, MacNee, W & Huang, JTJ 2016, 'Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD', European Respiratory Journal, vol. 47, no. 5, pp. 1365-1373. https://doi.org/10.1183/13993003.01824-2015

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T1 - Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

AU - Rabinovich, Roberto A.

AU - Miller, Bruce E.

AU - Wrobel, Karolina

AU - Ranjit, Kareshma

AU - Williams, Michelle C.

AU - Drost, Ellen

AU - Edwards, Lisa D.

AU - Lomas, David A.

AU - Rennard, Stephen I.

AU - Agusti, Alvar

AU - Tal-Singer, Ruth

AU - Vestbo, Jorgen

AU - Wouters, Emiel F. M.

AU - John, Michelle

AU - van Beek, Edwin J. R.

AU - Murchison, John T.

AU - Bolton, Charlotte E.

AU - MacNee, William

AU - Huang, Jeffrey T. J.

PY - 2016/5

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N2 - Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic-femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (p

AB - Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest computed tomography scans. Aortic arterial stiffness was measured as the aortic-femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (p

U2 - 10.1183/13993003.01824-2015

DO - 10.1183/13993003.01824-2015

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SN - 0903-1936

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JF - European Respiratory Journal

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