Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering applications

Cemre Günday, Shivesh Anand, Hikmet Burcu Gencer, Sara Munafò, Lorenzo Moroni, Alessandra Fusco, Giovanna Donnarumma, Claudio Ricci, Pinar Cakir Hatir, Nazende Günday Türeli*, Akif Emre Türeli, Carlos Mota, Serena Danti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Presented work focuses on the development of biodegradable polymer nanoparticles loaded with antibiotics as drug delivery systems deposited on electrospun scaffolds for tissue engineering. The innovative ciprofloxacin-loaded poly(DL-lactide-co-glycolide) NPs ensure a continuous slow release and high local concentration at the site of action for an optimal therapy. The local delivery of antibiotics as an integrated part of electrospun scaffolds offers an effective, safe, and smart enhancement supporting tissue regeneration. Presented data provides solid scientific evidence for fulfilling the requirements of local nano antibiotic delivery systems with biodegradability and biocompatibility for a wide range of tissue engineering applications, including middle ear tissues (e.g., tympanic membranes) which are subject to bacterial infections. Further characterization of such systems, including in vivo studies, is required to ensure successful transfer from lab to clinical applications. Graphical abstract .

Original languageEnglish
Pages (from-to)706-720
Number of pages15
JournalDrug Delivery and Translational Research
Volume10
Issue number3
Early online date25 Feb 2020
DOIs
Publication statusPublished - Jun 2020

Keywords

  • BIOMATERIALS
  • DESIGN
  • Electrospinning
  • INFECTIONS
  • Immunomodulation
  • MICROPARTICLES
  • NANOCARRIERS
  • NANOFIBERS
  • NANOMEDICINE
  • Nanoparticles
  • RELEASE
  • Regenerative medicine
  • SCAFFOLDS
  • SYSTEM
  • Stem cells

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