Chronic breathlessness in COPD: Effects of low-dose oral morphine

Cornelia Antonia Verberkt

doi:10.26481/dis.20211029cv

Chronic breathlessness in COPD: Effects of low-dose oral morphine

Cornelia Antonia Verberkt

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Why?
Breathlessness is the most common symptom in patients with advanced COPD and is often undertreated.

Purpose
Assessing the effect of morphine on:
• Quality of life
• Side effects
• Costs
Other purposes were to determine if a positive effect of morphine can be predicted and what the willingness of patients is to use opioids.

How?
• Literature study of side effects of opioids when prescribed for breathlessness;
• Intervention study with morphine tablets of placebo for 4 weeks in 124 patients with advanced COPD;
• Survey on willingness to use opioids.

Results
Morphine for 4 weeks improves quality of life in patients with advanced COPD and is cost-effective, without causing serious side effects. In patients with more severe breathlessness and a higher BMI, morphine more often leads to a positive effect. Finally, the willingness to use opioids is variable. The physician is an important source of information.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Wouters, Emiel, Supervisor van Everdingen - van den Beuken, Maria, Supervisor Janssen, Daisy, Co-Supervisor
Award date	29 Oct 2021
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789464166484
DOIs	https://doi.org/10.26481/dis.20211029cv
Publication status	Published - 2021

Keywords

breathlessness
morphine
COPD

Access to Document

10.26481/dis.20211029cv

Full TextFinal published version, 9.62 MB
CoverFinal published version, 48 KB
SummaryFinal published version, 1.54 MB
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Cite this

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title = "Chronic breathlessness in COPD: Effects of low-dose oral morphine",

abstract = "Why?Breathlessness is the most common symptom in patients with advanced COPD and is often undertreated.PurposeAssessing the effect of morphine on:• Quality of life• Side effects• CostsOther purposes were to determine if a positive effect of morphine can be predicted and what the willingness of patients is to use opioids.How?• Literature study of side effects of opioids when prescribed for breathlessness;• Intervention study with morphine tablets of placebo for 4 weeks in 124 patients with advanced COPD;• Survey on willingness to use opioids.ResultsMorphine for 4 weeks improves quality of life in patients with advanced COPD and is cost-effective, without causing serious side effects. In patients with more severe breathlessness and a higher BMI, morphine more often leads to a positive effect. Finally, the willingness to use opioids is variable. The physician is an important source of information. ",

keywords = "breathlessness, morphine, COPD",

author = "Verberkt, {Cornelia Antonia}",

year = "2021",

doi = "10.26481/dis.20211029cv",

language = "English",

isbn = "9789464166484",

publisher = "Maastricht University",

school = "Maastricht University",

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N2 - Why?Breathlessness is the most common symptom in patients with advanced COPD and is often undertreated.PurposeAssessing the effect of morphine on:• Quality of life• Side effects• CostsOther purposes were to determine if a positive effect of morphine can be predicted and what the willingness of patients is to use opioids.How?• Literature study of side effects of opioids when prescribed for breathlessness;• Intervention study with morphine tablets of placebo for 4 weeks in 124 patients with advanced COPD;• Survey on willingness to use opioids.ResultsMorphine for 4 weeks improves quality of life in patients with advanced COPD and is cost-effective, without causing serious side effects. In patients with more severe breathlessness and a higher BMI, morphine more often leads to a positive effect. Finally, the willingness to use opioids is variable. The physician is an important source of information.

AB - Why?Breathlessness is the most common symptom in patients with advanced COPD and is often undertreated.PurposeAssessing the effect of morphine on:• Quality of life• Side effects• CostsOther purposes were to determine if a positive effect of morphine can be predicted and what the willingness of patients is to use opioids.How?• Literature study of side effects of opioids when prescribed for breathlessness;• Intervention study with morphine tablets of placebo for 4 weeks in 124 patients with advanced COPD;• Survey on willingness to use opioids.ResultsMorphine for 4 weeks improves quality of life in patients with advanced COPD and is cost-effective, without causing serious side effects. In patients with more severe breathlessness and a higher BMI, morphine more often leads to a positive effect. Finally, the willingness to use opioids is variable. The physician is an important source of information.

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