TY - JOUR
T1 - Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis
AU - Been, Jasper V.
AU - Lievense, Sanne
AU - Zimmermann, Luc J. I.
AU - Kramer, Boris W.
AU - Wolfs, Tim G. A. M.
PY - 2013/2
Y1 - 2013/2
N2 - Objective To accumulate available evidence regarding the association between antenatal inflammation and necrotizing enterocolitis (NEC). Study design A systematic literature search was performed using Medline, Embase, Cochrane Library, ISI Web of Knowledge, and reference hand searches. Human studies published in English that reported associations between chorioamnionitis or other indicators of antenatal inflammation and NEC were eligible. Relevant associations were extracted and reported. Studies reporting associations between histological chorioamnionitis (HC) and NEC, HC with fetal involvement and NEC, and clinical chorioamnionitis and NEC were pooled in separate meta-analyses. Results A total of 33 relevant studies were identified. Clinical chorioamnionitis was significantly associated with NEC (12 studies; n = 22 601; OR, 1.24; 95% CI, 1.01-1.52; P = .04; I-2 = 12%), but the association between HC and NEC was not statistically significant (13 studies; n = 5889; OR, 1.39; 95% CI, 0.95-2.04; P = .09; I-2 = 49%). However, HC with fetal involvement was highly associated with NEC (3 studies; n = 1640; OR, 3.29; 95% CI, 1.87-5.78; P
AB - Objective To accumulate available evidence regarding the association between antenatal inflammation and necrotizing enterocolitis (NEC). Study design A systematic literature search was performed using Medline, Embase, Cochrane Library, ISI Web of Knowledge, and reference hand searches. Human studies published in English that reported associations between chorioamnionitis or other indicators of antenatal inflammation and NEC were eligible. Relevant associations were extracted and reported. Studies reporting associations between histological chorioamnionitis (HC) and NEC, HC with fetal involvement and NEC, and clinical chorioamnionitis and NEC were pooled in separate meta-analyses. Results A total of 33 relevant studies were identified. Clinical chorioamnionitis was significantly associated with NEC (12 studies; n = 22 601; OR, 1.24; 95% CI, 1.01-1.52; P = .04; I-2 = 12%), but the association between HC and NEC was not statistically significant (13 studies; n = 5889; OR, 1.39; 95% CI, 0.95-2.04; P = .09; I-2 = 49%). However, HC with fetal involvement was highly associated with NEC (3 studies; n = 1640; OR, 3.29; 95% CI, 1.87-5.78; P
U2 - 10.1016/j.jpeds.2012.07.012
DO - 10.1016/j.jpeds.2012.07.012
M3 - Article
C2 - 22920508
SN - 0022-3476
VL - 162
SP - 236
EP - 242
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -