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Casper D. J. den Heijer, Christian J. P. A. Hoebe, Johanna H. M. Driessen, Petra Wolffs, Ingrid V. F. van den Broek, Bernice M. Hoenderboom, Rachael Williams, Frank de Vries*, Nicole H. T. M. Dukers-Muijrers
Research output: Contribution to journal › Article › Academic › peer-review
Background. We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared with women who tested negative for CT and CT untested women, considering both targeted and incidental (ie, prescribed for another indication) use of CT-effective antibiotics.
Methods. This was a retrospective study of women aged 12-25 years at start of follow-up within the Clinical Practice Research Datalink GOLD database linked to index of multiple deprivation quintiles, 2000-2013. CT test status and antibiotic use were determined in a time-dependent manner. Risk of PID, ectopic pregnancy, or female infertility were evaluated using of Cox proportional hazard models.
Results. We studied 857 324 women, contributing 6 457 060 person-years. Compared with women who tested CT-negative, women who tested CT-positive had an increased risk of PID (adjusted hazard ratio [aHR], 2.36; 95% confidence interval [CI], 2.01-2.79), ectopic pregnancy (aHR, 1.87; 95% CI, 1.38-2.54), and infertility (aHR, 1.85; 95% CI, 1.27-2.68). The PID risk was higher for women with 2 or more positive CT tests than those with 1 positive test. PID risk increased with the number of previous antibiotic prescriptions, regardless of CT test status.
Conclusions. We showed an association between CT-positive tests and 3 adverse reproductive health outcomes. Moreover, this risk increased with repeat CT infections. CT-effective antibiotic use showed no decreased risks of subsequent PID regardless of CT history. Our results confirm the reproductive health burden of CT, which requires adequate public health interventions.
Original language | English |
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Pages (from-to) | 1517-1525 |
Number of pages | 9 |
Journal | Clinical Infectious Diseases |
Volume | 69 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Nov 2019 |
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic