Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.

R.M. Kwee, R.J. van Oostenbrugge, W.H. Mess, M.H. Prins, R.J. van der Geest, J.W. Ter Berg, CL. Franke, A.G. Korten, B.J. Meems, J.M. van Engelshoven, J.E. Wildberger, M.E. Kooi

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Abstract

Objective: To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). Materials and Methods: Forty transient ischemic attack/stroke patients with ipsilateral <70%><70%><70%> 0.05). Conclusions: In symptomatic patients with an ipsilateral carotid plaque causing <70%>year.
Original languageEnglish
Pages (from-to)803-809
JournalInvestigative Radiology
Volume45
Issue number12
DOIs
Publication statusPublished - 1 Jan 2010

Cite this

Kwee, R.M. ; van Oostenbrugge, R.J. ; Mess, W.H. ; Prins, M.H. ; van der Geest, R.J. ; Ter Berg, J.W. ; Franke, CL. ; Korten, A.G. ; Meems, B.J. ; van Engelshoven, J.M. ; Wildberger, J.E. ; Kooi, M.E. / Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging. In: Investigative Radiology. 2010 ; Vol. 45, No. 12. pp. 803-809.
@article{a790221352af4d359dec9be375c44d7c,
title = "Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.",
abstract = "Objective: To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). Materials and Methods: Forty transient ischemic attack/stroke patients with ipsilateral <70{\%} carotid stenosis underwent MRI of the plaque ipsilateral to the symptomatic side at baseline and after 1 year. The MRI protocol consisted of T1-weighted turbo field-echo, time-of-flight, T2-weighted turbo spin-echo (TSE), and pre- and postgadopentetate dimeglumine-enhanced T1-weighted TSE images. For each plaque, carotid lumen volume, wall volume, total vessel volume (=carotid lumen volume + wall volume), the presence of a lipid-rich necrotic core (LRNC), fibrous cap (FC) status, and the presence of intraplaque hemorrhage (IPH) were assessed at both time points. Results: Over a 1-year period, mean carotid lumen volume decreased with 4.8{\%} +/- 2.0{\%} (+/- standard error) (P = 0.013). Mean wall volume increased with 11.2{\%} +/- 2.2{\%} (P < 0.001). Total vessel volume did not significantly change (P = 0.147). At baseline, there were 18 plaques with a LRNC, which also had a LRNC at 1-year follow-up. No plaque without a LRNC at baseline developed a LRNC during the follow-up period. All plaques with a LRNC had a thin and/or ruptured FC at both time points. Twelve patients had IPH both at baseline and at follow-up. In one patient, IPH disappeared, whereas in another patient, new IPH appeared at follow-up. The presence of IPH and a LRNC with a thin and/or ruptured FC were not significantly associated with plaque progression (P > 0.05). Conclusions: In symptomatic patients with an ipsilateral carotid plaque causing <70{\%} stenosis, we found evidence for inward plaque remodeling over a 1-year period. Overall, the presence/absence of IPH, a LRNC, and FC status did not change over 1 year.",
author = "R.M. Kwee and {van Oostenbrugge}, R.J. and W.H. Mess and M.H. Prins and {van der Geest}, R.J. and {Ter Berg}, J.W. and CL. Franke and A.G. Korten and B.J. Meems and {van Engelshoven}, J.M. and J.E. Wildberger and M.E. Kooi",
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language = "English",
volume = "45",
pages = "803--809",
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issn = "0020-9996",
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Kwee, RM, van Oostenbrugge, RJ, Mess, WH, Prins, MH, van der Geest, RJ, Ter Berg, JW, Franke, CL, Korten, AG, Meems, BJ, van Engelshoven, JM, Wildberger, JE & Kooi, ME 2010, 'Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.', Investigative Radiology, vol. 45, no. 12, pp. 803-809. https://doi.org/10.1097/RLI.0b013e3181ed15ff

Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging. / Kwee, R.M.; van Oostenbrugge, R.J.; Mess, W.H.; Prins, M.H.; van der Geest, R.J.; Ter Berg, J.W.; Franke, CL.; Korten, A.G.; Meems, B.J.; van Engelshoven, J.M.; Wildberger, J.E.; Kooi, M.E.

In: Investigative Radiology, Vol. 45, No. 12, 01.01.2010, p. 803-809.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.

AU - Kwee, R.M.

AU - van Oostenbrugge, R.J.

AU - Mess, W.H.

AU - Prins, M.H.

AU - van der Geest, R.J.

AU - Ter Berg, J.W.

AU - Franke, CL.

AU - Korten, A.G.

AU - Meems, B.J.

AU - van Engelshoven, J.M.

AU - Wildberger, J.E.

AU - Kooi, M.E.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objective: To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). Materials and Methods: Forty transient ischemic attack/stroke patients with ipsilateral <70% carotid stenosis underwent MRI of the plaque ipsilateral to the symptomatic side at baseline and after 1 year. The MRI protocol consisted of T1-weighted turbo field-echo, time-of-flight, T2-weighted turbo spin-echo (TSE), and pre- and postgadopentetate dimeglumine-enhanced T1-weighted TSE images. For each plaque, carotid lumen volume, wall volume, total vessel volume (=carotid lumen volume + wall volume), the presence of a lipid-rich necrotic core (LRNC), fibrous cap (FC) status, and the presence of intraplaque hemorrhage (IPH) were assessed at both time points. Results: Over a 1-year period, mean carotid lumen volume decreased with 4.8% +/- 2.0% (+/- standard error) (P = 0.013). Mean wall volume increased with 11.2% +/- 2.2% (P < 0.001). Total vessel volume did not significantly change (P = 0.147). At baseline, there were 18 plaques with a LRNC, which also had a LRNC at 1-year follow-up. No plaque without a LRNC at baseline developed a LRNC during the follow-up period. All plaques with a LRNC had a thin and/or ruptured FC at both time points. Twelve patients had IPH both at baseline and at follow-up. In one patient, IPH disappeared, whereas in another patient, new IPH appeared at follow-up. The presence of IPH and a LRNC with a thin and/or ruptured FC were not significantly associated with plaque progression (P > 0.05). Conclusions: In symptomatic patients with an ipsilateral carotid plaque causing <70% stenosis, we found evidence for inward plaque remodeling over a 1-year period. Overall, the presence/absence of IPH, a LRNC, and FC status did not change over 1 year.

AB - Objective: To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). Materials and Methods: Forty transient ischemic attack/stroke patients with ipsilateral <70% carotid stenosis underwent MRI of the plaque ipsilateral to the symptomatic side at baseline and after 1 year. The MRI protocol consisted of T1-weighted turbo field-echo, time-of-flight, T2-weighted turbo spin-echo (TSE), and pre- and postgadopentetate dimeglumine-enhanced T1-weighted TSE images. For each plaque, carotid lumen volume, wall volume, total vessel volume (=carotid lumen volume + wall volume), the presence of a lipid-rich necrotic core (LRNC), fibrous cap (FC) status, and the presence of intraplaque hemorrhage (IPH) were assessed at both time points. Results: Over a 1-year period, mean carotid lumen volume decreased with 4.8% +/- 2.0% (+/- standard error) (P = 0.013). Mean wall volume increased with 11.2% +/- 2.2% (P < 0.001). Total vessel volume did not significantly change (P = 0.147). At baseline, there were 18 plaques with a LRNC, which also had a LRNC at 1-year follow-up. No plaque without a LRNC at baseline developed a LRNC during the follow-up period. All plaques with a LRNC had a thin and/or ruptured FC at both time points. Twelve patients had IPH both at baseline and at follow-up. In one patient, IPH disappeared, whereas in another patient, new IPH appeared at follow-up. The presence of IPH and a LRNC with a thin and/or ruptured FC were not significantly associated with plaque progression (P > 0.05). Conclusions: In symptomatic patients with an ipsilateral carotid plaque causing <70% stenosis, we found evidence for inward plaque remodeling over a 1-year period. Overall, the presence/absence of IPH, a LRNC, and FC status did not change over 1 year.

U2 - 10.1097/RLI.0b013e3181ed15ff

DO - 10.1097/RLI.0b013e3181ed15ff

M3 - Article

VL - 45

SP - 803

EP - 809

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 12

ER -