@article{3de37d0515aa43ffa9e45921e3d28552,
title = "Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart",
abstract = "In western countries, cardiovascular (CV) disease and cancer are the leading causes of death in the ageing population. Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident CV disease, in particular, heart failure (HF). Indeed, there is a tight link in terms of shared risk factors and mechanisms between HF and cancer. HF induced by anticancer therapies has been extensively studied, primarily focusing on the toxic effects that anti-tumour treatments exert on cardiomyocytes. In this Cardio-Oncology update, members of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart discuss novel evidence interconnecting cardiac dysfunction and cancer via pathways in which cardiomyocytes may be involved but are not central. In particular, the multiple roles of cardiac stromal cells (endothelial cells and fibroblasts) and inflammatory cells are highlighted. Also, the gut microbiota is depicted as a new player at the crossroads between HF and cancer. Finally, the role of non-coding RNAs in Cardio-Oncology is also addressed. All these insights are expected to fuel additional research efforts in the field of Cardio-Oncology.",
keywords = "Cardio-Oncology, Common pathways in heart failure and cancer, Multicellular and multiorgan mechanisms, DOXORUBICIN-INDUCED CARDIOTOXICITY, PRESERVED EJECTION FRACTION, IMMUNE CHECKPOINT INHIBITORS, CHAIN FATTY-ACIDS, CLONAL HEMATOPOIESIS, HISTONE DEACETYLASE, EUROPEAN-SOCIETY, LUNG-CANCER, CARDIOVASCULAR-DISEASE, INFLAMMATORY RESPONSES",
author = "Tocchetti, {Carlo Gabriele} and Pietro Ameri and {de Boer}, {Rudolf A.} and Yuri D'Alessandra and Michele Russo and Daniela Sorriento and Michele Ciccarelli and Bernadett Kiss and Luc Bertrand and Dana Dawson and Ines Falcao-Pires and Mauro Giacca and Nazha Hamdani and Linke, {Wolfgang A.} and Manuel Mayr and {van der Velden}, Jolanda and Serena Zacchigna and Alessandra Ghigo and Emilio Hirsch and Lyon, {Alexander R.} and Aniko Gorbe and Peter Ferdinandy and Rosalinda Madonna and Stephane Heymans and Thomas Thum",
note = "Funding Information: We acknowledge the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, CVON She-PREDICTS, grant 2017-21, CVON Arena-PRIME, 2017-18. Furthermore, we acknowledge the support of FWO G091018N and FWO G0B5930N to S.H. I.F.P. was supported by Fundo Europeu de Desenvolvimento Regional (FEDER) through Compete 2020 - Programa Operacional Competitividade E Internacionaliza{\c c}{\~a}o (POCI), the project DOCNET (norte-01-0145-feder-000003) was supported by Norte Portugal regional operational programme (norte 2020), under the Portugal 2020 partnership agreement, through the European Regional Development Fund (ERDF). C.G.T. was supported by a Ricerca di Ateneo/Federico II University grant, P.A. is supported by the Italian Ministry of Health (GR-2018-12365661, CHANGE Study), P.F. was supported by the National Research, Development and Innovation Office of Hungary (Research Excellence Program - TKP, National Heart Program NVKP 16-1-2016-0017; 2019-1.1.1-PIACI-KFI-2019-00367) and by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic programme of the Semmelweis University. T.T. received funding from the EU-ERANET grant EXPERT. L.B. is Research director of FRS-FNRS, Belgium, R.M. received funding from Incyte Biosciences. R.A.d.B. was supported by the European Research Council (ERC CoG 818715, SECRETE-HF) and the CVON grants from Netherlands Heart Foundation (DOSIS, 2014-40; SHE-PREDICTS-HF, 2017-21; RED-CVD, 2017-11; and PREDICT2, 2018-30). This manuscript has been possible thanks to the support of the ERA-Net-CVD project MacroERA, 01KL1706, and IMI2-CARDIATEAM (N 821508) to S.H., Associazione Italiana per la Ricerca sul Cancro (AIRC) IG 2016 Id.19032 to SZ, Leducq 09CVD01 {"}Targeted Approaches for Prevention and Treatment of Anthracycline-Induced Cardiotoxicity{"} to E.H. and A.G. Publisher Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2020.; Myocardial Function & Cellular Biology of the Heart Meeting ; Conference date: 09-05-2019 Through 11-05-2019",
year = "2020",
month = sep,
day = "1",
doi = "10.1093/cvr/cvaa222",
language = "English",
volume = "116",
pages = "1820--1834",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "11",
url = "https://www.escardio.org/Working-groups/Working-Group-on-Cellular-Biology-of-the-Heart/Meetings/Myocardial-Function-Cellular-Biology-of-the-Heart-Meeting",
}