TY - JOUR
T1 - Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2
AU - Tangos, Melina
AU - Jarkas, Muhammad
AU - Akin, Ibrahim
AU - El-Battrawy, Ibrahim
AU - Hamdani, Nazha
PY - 2024/4/22
Y1 - 2024/4/22
N2 - Until now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention. In this review, we highlight cardiac manifestations that might arise from an infection with SARS-CoV-2 and provide an overview of known comorbidities that worsen the outcome. Additionally, we aim to summarize the therapeutic strategies proposed to reverse virus-associated myocardial damage, which will be further highlighted in this review, with an outlook to successful recovery and prevention.
AB - Until now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention. In this review, we highlight cardiac manifestations that might arise from an infection with SARS-CoV-2 and provide an overview of known comorbidities that worsen the outcome. Additionally, we aim to summarize the therapeutic strategies proposed to reverse virus-associated myocardial damage, which will be further highlighted in this review, with an outlook to successful recovery and prevention.
U2 - 10.1016/j.mib.2024.102437
DO - 10.1016/j.mib.2024.102437
M3 - (Systematic) Review article
SN - 1879-0364
VL - 78
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
M1 - 102437
ER -