Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction

Ever Espino-Gonzalez; Peter G. Tickle; Raffaele Altara; Harrison Gallagher; Chew W. Cheng; Viktor Engman; Nathanael Wood; Gustavo Jose Justo da Silva; Mattia Scalabrin; Xinyue Yu; Ziyi Zhong; Michael A. Colman; Nadira Y. Yuldasheva; George W. Booz; Volker Adams; Marcelo G. Pereira; Alessandro Cataliotti; Lee D. Roberts; Stuart Egginton; T. Scott Bowen

doi:10.1016/j.jacbts.2023.09.014

Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction

Ever Espino-Gonzalez, Peter G. Tickle, Raffaele Altara, Harrison Gallagher, Chew W. Cheng, Viktor Engman, Nathanael Wood, Gustavo Jose Justo da Silva, Mattia Scalabrin, Xinyue Yu, Ziyi Zhong, Michael A. Colman, Nadira Y. Yuldasheva, George W. Booz, Volker Adams, Marcelo G. Pereira, Alessandro Cataliotti, Lee D. Roberts, Stuart Egginton, T. Scott Bowen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a major clinical problem, with limited treatments. HFpEF is characterized by a distinct, but poorly understood, skeletal muscle pathology, which could offer an alternative therapeutic target. In a rat model, we identified impaired myonuclear accretion as a mechanism for low myofiber growth in HFpEF following resistance exercise. Acute caloric restriction rescued skeletal muscle pathology in HFpEF, whereas cardiac therapies had no effect. Mechanisms regulating myonuclear accretion were dysregulated in patients with HFpEF. Overall, these findings may have widespread implications in HFpEF, indicating combined dietary with exercise interventions as a beneficial approach to overcome skeletal muscle pathology.

Original language	English
Pages (from-to)	223-240
Number of pages	18
Journal	JACC: Basic to Translational Science
Volume	9
Issue number	2
Early online date	1 Jan 2024
DOIs	https://doi.org/10.1016/j.jacbts.2023.09.014
Publication status	Published - Feb 2024

Keywords

HFpEF
diet
exercise training
mitochondria
skeletal muscle

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Cite this

Espino-Gonzalez, E., Tickle, P. G., Altara, R., Gallagher, H., Cheng, C. W., Engman, V., Wood, N., Justo da Silva, G. J., Scalabrin, M., Yu, X., Zhong, Z., Colman, M. A., Yuldasheva, N. Y., Booz, G. W., Adams, V., Pereira, M. G., Cataliotti, A., Roberts, L. D., Egginton, S., & Bowen, T. S. (2024). Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science, 9(2), 223-240. https://doi.org/10.1016/j.jacbts.2023.09.014

@article{b4a2f728455344a79d0ff04a499f4a29,

title = "Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction",

abstract = "Heart failure with preserved ejection fraction (HFpEF) is a major clinical problem, with limited treatments. HFpEF is characterized by a distinct, but poorly understood, skeletal muscle pathology, which could offer an alternative therapeutic target. In a rat model, we identified impaired myonuclear accretion as a mechanism for low myofiber growth in HFpEF following resistance exercise. Acute caloric restriction rescued skeletal muscle pathology in HFpEF, whereas cardiac therapies had no effect. Mechanisms regulating myonuclear accretion were dysregulated in patients with HFpEF. Overall, these findings may have widespread implications in HFpEF, indicating combined dietary with exercise interventions as a beneficial approach to overcome skeletal muscle pathology.",

keywords = "HFpEF, diet, exercise training, mitochondria, skeletal muscle",

author = "Ever Espino-Gonzalez and Tickle, {Peter G.} and Raffaele Altara and Harrison Gallagher and Cheng, {Chew W.} and Viktor Engman and Nathanael Wood and {Justo da Silva}, {Gustavo Jose} and Mattia Scalabrin and Xinyue Yu and Ziyi Zhong and Colman, {Michael A.} and Yuldasheva, {Nadira Y.} and Booz, {George W.} and Volker Adams and Pereira, {Marcelo G.} and Alessandro Cataliotti and Roberts, {Lee D.} and Stuart Egginton and Bowen, {T. Scott}",

note = "Funding Information: The authors thank Prof Michelle Peckham, University of Leeds, for providing critical comments. Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = feb,

doi = "10.1016/j.jacbts.2023.09.014",

language = "English",

volume = "9",

pages = "223--240",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

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Espino-Gonzalez, E, Tickle, PG, Altara, R, Gallagher, H, Cheng, CW, Engman, V, Wood, N, Justo da Silva, GJ, Scalabrin, M, Yu, X, Zhong, Z, Colman, MA, Yuldasheva, NY, Booz, GW, Adams, V, Pereira, MG, Cataliotti, A, Roberts, LD, Egginton, S & Bowen, TS 2024, 'Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction', JACC: Basic to Translational Science, vol. 9, no. 2, pp. 223-240. https://doi.org/10.1016/j.jacbts.2023.09.014

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AU - Espino-Gonzalez, Ever

AU - Tickle, Peter G.

AU - Altara, Raffaele

AU - Gallagher, Harrison

AU - Cheng, Chew W.

AU - Engman, Viktor

AU - Wood, Nathanael

AU - Justo da Silva, Gustavo Jose

AU - Scalabrin, Mattia

AU - Yu, Xinyue

AU - Zhong, Ziyi

AU - Colman, Michael A.

AU - Yuldasheva, Nadira Y.

AU - Booz, George W.

AU - Adams, Volker

AU - Pereira, Marcelo G.

AU - Cataliotti, Alessandro

AU - Roberts, Lee D.

AU - Egginton, Stuart

AU - Bowen, T. Scott

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KW - HFpEF

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