Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik; Xia Yang; Tokio Mimura; Zeinab Tahmasebi Birgani; Pamela Habibovic; Kiyoshi Itatani; John A. Jansen; Jons Hilborn; Dmitri Ossipov; Antonios G. Mikos; Sander C. G. Leeuwenburgh

doi:10.1002/mabi.201300117

Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik, Xia Yang, Tokio Mimura, Zeinab Tahmasebi Birgani, Pamela Habibovic, Kiyoshi Itatani, John A. Jansen, Jons Hilborn, Dmitri Ossipov, Antonios G. Mikos, Sander C. G. Leeuwenburgh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1308-1313
Number of pages	6
Journal	Macromolecular Bioscience
Volume	13
Issue number	10
DOIs	https://doi.org/10.1002/mabi.201300117
Publication status	Published - Oct 2013
Externally published	Yes

Keywords

SURFACE MODIFICATION
POLYMER NETWORKS
NANOPARTICLES
METALLOPOLYMERS
IONS

Access to Document

10.1002/mabi.201300117

Cite this

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title = "Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels",

abstract = "This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.{\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "SURFACE MODIFICATION, POLYMER NETWORKS, NANOPARTICLES, METALLOPOLYMERS, IONS",

author = "Nejadnik, {M. Reza} and Xia Yang and Tokio Mimura and Birgani, {Zeinab Tahmasebi} and Pamela Habibovic and Kiyoshi Itatani and Jansen, {John A.} and Jons Hilborn and Dmitri Ossipov and Mikos, {Antonios G.} and Leeuwenburgh, {Sander C. G.}",

year = "2013",

month = oct,

doi = "10.1002/mabi.201300117",

language = "English",

volume = "13",

pages = "1308--1313",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "John Wiley & Sons Inc.",

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}

TY - JOUR

T1 - Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

AU - Nejadnik, M. Reza

AU - Yang, Xia

AU - Mimura, Tokio

AU - Birgani, Zeinab Tahmasebi

AU - Habibovic, Pamela

AU - Itatani, Kiyoshi

AU - Jansen, John A.

AU - Hilborn, Jons

AU - Ossipov, Dmitri

AU - Mikos, Antonios G.

AU - Leeuwenburgh, Sander C. G.

PY - 2013/10

Y1 - 2013/10

N2 - This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - SURFACE MODIFICATION

KW - POLYMER NETWORKS

KW - NANOPARTICLES

KW - METALLOPOLYMERS

KW - IONS

U2 - 10.1002/mabi.201300117

DO - 10.1002/mabi.201300117

M3 - Article

SN - 1616-5187

VL - 13

SP - 1308

EP - 1313

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 10

ER -