Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Karin J. C. Sanders, Anita E. M. Kneppers, Coby van de Bool, Ramon C. J. Langen, Annemie M. W. J. Schols*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Web of Science)


Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD-induced cachexia.
Original languageEnglish
Pages (from-to)5-22
JournalJournal of cachexia, sarcopenia and muscle
Issue number1
Publication statusPublished - Mar 2016


  • COPD
  • Muscle
  • Emphysema
  • Energy balance
  • Cachexia
  • Lung cancer

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