Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Karin J. C. Sanders, Anita E. M. Kneppers, Coby van de Bool, Ramon C. J. Langen, Annemie M. W. J. Schols*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Web of Science)

Abstract

Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD-induced cachexia.
Original languageEnglish
Pages (from-to)5-22
JournalJournal of cachexia, sarcopenia and muscle
Volume7
Issue number1
DOIs
Publication statusPublished - Mar 2016

Keywords

  • COPD
  • Muscle
  • Emphysema
  • Energy balance
  • Cachexia
  • Lung cancer

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