TY - JOUR
T1 - Brush-Like Coatings Provide A Cloak of Invisibility to Titanium Implants
AU - Witzdam, Lena
AU - Garay-Sarmiento, Manuela
AU - Gagliardi, Mick
AU - Meurer, Yannick L
AU - Rutsch, Yannik
AU - Englert, Jenny
AU - Philipsen, Sandra
AU - Janem, Anisa
AU - Alsheghri, Rawan
AU - Jakob, Felix
AU - Molin, Daniël G M
AU - Schwaneberg, Ulrich
AU - van den Akker, Nynke M S
AU - Rodriguez-Emmenegger, Cesar
PY - 2024/4
Y1 - 2024/4
N2 - Orthopedic implants such as knee and hip implants are one of the most important types of medical devices. Currently, the surface of the most advanced implants consists of titanium or titanium-alloys with high porosity at the bone-contacting surface leading to superior mechanical properties, excellent biocompatibility, and the capability of inducing osseointegration. However, the increased surface area of porous titanium provides a nidus for bacteria colonization leading to implant-related infections, one of the main reasons for implant failure. Here, we develop two readily applicable titanium-coatings based on hydrophilic carboxybetaine polymers that turn the surface stealth thereby preventing bacterial adhesion and colonization. These coatings are biocompatible, do not affect cell functionality, exhibit great antifouling properties, and do not cause additional inflammation during the healing process. In this way, the coatings can prevent implant-related infections, while at the same time being completely innocuous to its biological environment. Thus, these coating strategies are a promising route to enhance the biocompatibility of orthopedic implants and have a high potential for clinical use, while being easy to implement in the implant manufacturing process. This article is protected by copyright. All rights reserved.
AB - Orthopedic implants such as knee and hip implants are one of the most important types of medical devices. Currently, the surface of the most advanced implants consists of titanium or titanium-alloys with high porosity at the bone-contacting surface leading to superior mechanical properties, excellent biocompatibility, and the capability of inducing osseointegration. However, the increased surface area of porous titanium provides a nidus for bacteria colonization leading to implant-related infections, one of the main reasons for implant failure. Here, we develop two readily applicable titanium-coatings based on hydrophilic carboxybetaine polymers that turn the surface stealth thereby preventing bacterial adhesion and colonization. These coatings are biocompatible, do not affect cell functionality, exhibit great antifouling properties, and do not cause additional inflammation during the healing process. In this way, the coatings can prevent implant-related infections, while at the same time being completely innocuous to its biological environment. Thus, these coating strategies are a promising route to enhance the biocompatibility of orthopedic implants and have a high potential for clinical use, while being easy to implement in the implant manufacturing process. This article is protected by copyright. All rights reserved.
KW - Titanium implants
KW - antifouling surfaces
KW - bacteria repellency
KW - biocompatibility
KW - brushes
KW - stealth coatings
U2 - 10.1002/mabi.202300434
DO - 10.1002/mabi.202300434
M3 - Article
SN - 1616-5187
VL - 24
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 4
M1 - 2300434
ER -