Brain-related comorbidities in boys and men with Duchenne Muscular Dystrophy: A descriptive study

Ruben G. F. Hendriksen*, Johan S. H. Vles*, Marlien W. Aalbers*, Richard F. M. Chin*, Jos G. M. Hendriksen*

*Corresponding author for this work

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Abstract

Aim: Duchenne Muscular Dystrophy (DMD) is more than a muscle disease since there is a higher prevalence of neuropsychological comorbidities. Similarly, the prevalence of epilepsy is increased. Given the nowadays-increasing interest in brain-related comorbidities in DMD, this study aimed to evaluate the relationship between DMD, epilepsy, and associated neurodevelopmental disorders in an international sample of DMD patients. Method: Using a questionnaire-based study we investigated the occurrence of self/by-proxy reported brain-related comorbidities in a group of 228 DMD patients. We evaluated the presence of epilepsy and other brain-related comorbidities, but also the specific mutation in the dystrophin gene. With respect to epilepsy, all individually reported epilepsy cases as based on the questionnaire results including information provided on epilepsy treatment, EEG abnormalities, and a description of how a typical seizure would look like, were independently and blindly re-assessed by two external paediatric neurologists (Cohen's kappa of 0.85). Results: Based on the latter, 18 (7.9%) DMD patients were considered to have epilepsy. In patients with both DMD and epilepsy, certain other brain-related comorbidities (i.e. attention deficit hyperactivity disorder, obsessive compulsive disorder, anxiety disorders and sleep disorders) were significantly more prevalent. Conclusion: This study is supportive of a high occurrence of epilepsy and other brain-related comorbidities in DMD. Furthermore this study shows for the first time that the frequency of some of these disorders appear to be further increased when epilepsy is present next to DMD. As this study is limited by the self/by proxy setup and the lack of response rates, future studies should elucidate the true incidence of the (triangular) cooccurrence between epilepsy, neurodevelopmental deficits, and DMD. (C) 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)488-497
Number of pages10
JournalEuropean Journal of Paediatric Neurology
Volume22
Issue number3
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Duchenne Muscular Dystrophy
  • Epilepsy
  • Seizures
  • Neurodevelopmental disorders
  • Sleep disorders
  • Questionnaire study
  • DEFICIT HYPERACTIVITY DISORDER
  • AUTISM SPECTRUM DISORDER
  • COGNITIVE IMPAIRMENT
  • DP140
  • EPILEPSY
  • MALES
  • EPIDEMIOLOGY
  • ORGANIZATION
  • RETARDATION
  • ASSOCIATION

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