BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study

Emmanuel Cognat; Séverine Sabia; Alexandra Fayel; Matthieu Lilamand; Ron Handels; Sara Fascendini; Sverre Bergh; Giovanni B. Frisoni; Andrea Fabbo; Magdalina Tsolaki; Lutz Frölich; Oliver Peters; Paola Merlo; Alfonso Ciccone; Patrizia Mecocci; Julien Dumurgier; Carlo A. Defanti; Jacques Hugon; Claire Paquet

doi:10.1016/j.jagp.2023.03.014

BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study

Emmanuel Cognat^*, Séverine Sabia, Alexandra Fayel, Matthieu Lilamand, Ron Handels, Sara Fascendini, Sverre Bergh, Giovanni B. Frisoni, Andrea Fabbo, Magdalina Tsolaki, Lutz Frölich, Oliver Peters, Paola Merlo, Alfonso Ciccone, Patrizia Mecocci, Julien Dumurgier, Carlo A. Defanti, Jacques Hugon, Claire Paquet

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Downloads (Pure)

Abstract

Objective: Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. Methods: We analyzed data collected at baseline in 398 patients with severe BPSD (NPI = 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. Results: Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. Conclusion: Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.

Original language	English
Pages (from-to)	633-639
Number of pages	7
Journal	American Journal of Geriatric Psychiatry
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.jagp.2023.03.014
Publication status	Published - 1 Aug 2023

Keywords

Agitation
Alzheimer's disease
clinical profile
frontotemporal dementia
Lewy body dementia
neuropsychiatric inventory

Access to Document

10.1016/j.jagp.2023.03.014

Full TextFinal published version, 668 KBLicence: Taverne

Cite this

Cognat, E., Sabia, S., Fayel, A., Lilamand, M., Handels, R., Fascendini, S., Bergh, S., Frisoni, G. B., Fabbo, A., Tsolaki, M., Frölich, L., Peters, O., Merlo, P., Ciccone, A., Mecocci, P., Dumurgier, J., Defanti, C. A., Hugon, J., & Paquet, C. (2023). BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study. American Journal of Geriatric Psychiatry, 31(8), 633-639. https://doi.org/10.1016/j.jagp.2023.03.014

@article{6b95550e312f4efb92f9e6d42037afc4,

title = "BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study",

abstract = "Objective: Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. Methods: We analyzed data collected at baseline in 398 patients with severe BPSD (NPI = 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. Results: Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. Conclusion: Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.",

keywords = "Agitation, Alzheimer's disease, clinical profile, frontotemporal dementia, Lewy body dementia, neuropsychiatric inventory",

author = "Emmanuel Cognat and S{\'e}verine Sabia and Alexandra Fayel and Matthieu Lilamand and Ron Handels and Sara Fascendini and Sverre Bergh and Frisoni, {Giovanni B.} and Andrea Fabbo and Magdalina Tsolaki and Lutz Fr{\"o}lich and Oliver Peters and Paola Merlo and Alfonso Ciccone and Patrizia Mecocci and Julien Dumurgier and Defanti, {Carlo A.} and Jacques Hugon and Claire Paquet",

note = "Funding Information: This publication has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 779237 . Authors declare no competing interests relating to the topic of this study. Publisher Copyright: {\textcopyright} 2023 American Association for Geriatric Psychiatry",

year = "2023",

month = aug,

day = "1",

doi = "10.1016/j.jagp.2023.03.014",

language = "English",

volume = "31",

pages = "633--639",

journal = "American Journal of Geriatric Psychiatry",

issn = "1064-7481",

publisher = "Elsevier Science",

number = "8",

}

Cognat, E, Sabia, S, Fayel, A, Lilamand, M, Handels, R, Fascendini, S, Bergh, S, Frisoni, GB, Fabbo, A, Tsolaki, M, Frölich, L, Peters, O, Merlo, P, Ciccone, A, Mecocci, P, Dumurgier, J, Defanti, CA, Hugon, J & Paquet, C 2023, 'BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study', American Journal of Geriatric Psychiatry, vol. 31, no. 8, pp. 633-639. https://doi.org/10.1016/j.jagp.2023.03.014

TY - JOUR

T1 - BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances

T2 - Insight From the RECAGE Study

AU - Cognat, Emmanuel

AU - Sabia, Séverine

AU - Fayel, Alexandra

AU - Lilamand, Matthieu

AU - Handels, Ron

AU - Fascendini, Sara

AU - Bergh, Sverre

AU - Frisoni, Giovanni B.

AU - Fabbo, Andrea

AU - Tsolaki, Magdalina

AU - Frölich, Lutz

AU - Peters, Oliver

AU - Merlo, Paola

AU - Ciccone, Alfonso

AU - Mecocci, Patrizia

AU - Dumurgier, Julien

AU - Defanti, Carlo A.

AU - Hugon, Jacques

AU - Paquet, Claire

N1 - Funding Information: This publication has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 779237 . Authors declare no competing interests relating to the topic of this study. Publisher Copyright: © 2023 American Association for Geriatric Psychiatry

PY - 2023/8/1

Y1 - 2023/8/1

N2 - Objective: Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. Methods: We analyzed data collected at baseline in 398 patients with severe BPSD (NPI = 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. Results: Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. Conclusion: Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.

AB - Objective: Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. Methods: We analyzed data collected at baseline in 398 patients with severe BPSD (NPI = 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. Results: Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. Conclusion: Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.

KW - Agitation

KW - Alzheimer's disease

KW - clinical profile

KW - frontotemporal dementia

KW - Lewy body dementia

KW - neuropsychiatric inventory

U2 - 10.1016/j.jagp.2023.03.014

DO - 10.1016/j.jagp.2023.03.014

M3 - Article

C2 - 37183097

SN - 1064-7481

VL - 31

SP - 633

EP - 639

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

IS - 8

ER -