Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin

Michiel P. de Boer; Nienke J. Wijnstok; Erik H. Serne; Etto C. Eringa; Coen D. A. Stehouwer; Allan Flyvbjerg; Trynke Hoekstra; Martijn W. Heymans; Rick I. Meijer; Jos W. Twisk; Yvo M. Smulders

doi:10.1111/eci.12284

Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin

Michiel P. de Boer^*, Nienke J. Wijnstok, Erik H. Serne, Etto C. Eringa, Coen D. A. Stehouwer, Allan Flyvbjerg, Trynke Hoekstra, Martijn W. Heymans, Rick I. Meijer, Jos W. Twisk, Yvo M. Smulders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P

Original language	English
Pages (from-to)	660-667
Journal	European Journal of Clinical Investigation
Volume	44
Issue number	7
DOIs	https://doi.org/10.1111/eci.12284
Publication status	Published - Jul 2014

Keywords

Adiponectin
BMI
microcirculation
vasomotion

Access to Document

10.1111/eci.12284

Cite this

de Boer, M. P., Wijnstok, N. J., Serne, E. H., Eringa, E. C., Stehouwer, C. D. A., Flyvbjerg, A., Hoekstra, T., Heymans, M. W., Meijer, R. I., Twisk, J. W., & Smulders, Y. M. (2014). Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin. European Journal of Clinical Investigation, 44(7), 660-667. https://doi.org/10.1111/eci.12284

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title = "Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin",

abstract = "Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P",

keywords = "Adiponectin, BMI, microcirculation, vasomotion",

author = "{de Boer}, {Michiel P.} and Wijnstok, {Nienke J.} and Serne, {Erik H.} and Eringa, {Etto C.} and Stehouwer, {Coen D. A.} and Allan Flyvbjerg and Trynke Hoekstra and Heymans, {Martijn W.} and Meijer, {Rick I.} and Twisk, {Jos W.} and Smulders, {Yvo M.}",

year = "2014",

month = jul,

doi = "10.1111/eci.12284",

language = "English",

volume = "44",

pages = "660--667",

journal = "European Journal of Clinical Investigation",

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number = "7",

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AU - de Boer, Michiel P.

AU - Wijnstok, Nienke J.

AU - Serne, Erik H.

AU - Eringa, Etto C.

AU - Stehouwer, Coen D. A.

AU - Flyvbjerg, Allan

AU - Hoekstra, Trynke

AU - Heymans, Martijn W.

AU - Meijer, Rick I.

AU - Twisk, Jos W.

AU - Smulders, Yvo M.

PY - 2014/7

Y1 - 2014/7

N2 - Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P

AB - Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P

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KW - microcirculation

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