Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin

Michiel P. de Boer*, Nienke J. Wijnstok, Erik H. Serne, Etto C. Eringa, Coen D. A. Stehouwer, Allan Flyvbjerg, Trynke Hoekstra, Martijn W. Heymans, Rick I. Meijer, Jos W. Twisk, Yvo M. Smulders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42years, 46 men, mean BMI 255 +/- 38kg/m2) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF). Results BMI was associated with the neurogenic domain of the vasomotion spectrum ( -0011, P=0046), adiponectin ( -018, P=0028) and leptin ( 222, P
Original languageEnglish
Pages (from-to)660-667
JournalEuropean Journal of Clinical Investigation
Volume44
Issue number7
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Adiponectin
  • BMI
  • microcirculation
  • vasomotion

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