TY - JOUR
T1 - Blood coagulation and beyond
T2 - Position paper from the Fourth Maastricht Consensus Conference on Thrombosis
AU - Akbalut, Cengiz
AU - Arisz, Ryanne
AU - Baaten, Constance
AU - Baildildinova, Gaukhar
AU - Barakzie, Aarazo
AU - Bauersachs, Rupert
AU - Ten Berg, Jurriën M
AU - van den Broek, Wout
AU - de Boer, Hetty C
AU - Broker, Vanessa
AU - Buka, Richard
AU - Ten Cate, Hugo
AU - Cate, Arina Ten
AU - De Luca, Ciro
AU - De Simone, Ilaria
AU - Dignat-George, Françoise
AU - Freson, Kathleen
AU - Gazzaniga, Giulia
AU - van Gorp, Eric
AU - Habibi, Anxhela
AU - Henskens, Yvonne M C
AU - Iding, Aaron F J
AU - Khan, Abdullah
AU - Koenderink, Gijsje
AU - Konkoth, Akhil
AU - Lacroix, Romaric
AU - Lahiri, Trisha
AU - Lam, Wilbur
AU - Lamerton, Rachel
AU - Lorusso, Roberto
AU - Luo, Qi
AU - Maas, Coen
AU - McCarty, Owen J T
AU - van der Meijden, Paola
AU - Meijers, Joost
AU - Mohapatra, Adarsh
AU - Nevo, Neta
AU - Pallares Robles, Alejandro
AU - Poncelet, Philippe
AU - Reinhardt, Christoph
AU - Ruf, Wolfram
AU - Saraswat, Ronald
AU - Schonichen, Claudia
AU - Schutgens, Roger E G
AU - Simioni, Paolo
AU - Spada, Stefano
AU - Spronk, Henri M H
AU - Tazhibayeva, Karlygash
AU - Thachil, Jecko
AU - Vacik-Diaz, Rocio
AU - Veninga, Alicia
AU - Verhamme, Peter
AU - Visser, Chantal
AU - Watson, Steve P
AU - Wenzel, Philip
AU - Willems, Ruth
AU - Willers, Anne
AU - Zhang, Pengyu
AU - Zifkos, Konstantinos
AU - van Zonneveld, Anton-Jan
N1 - The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
PY - 2023/5/12
Y1 - 2023/5/12
N2 - The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The "coagulome" as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.
AB - The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The "coagulome" as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.
U2 - 10.1055/a-2052-9175
DO - 10.1055/a-2052-9175
M3 - Editorial
C2 - 36913975
SN - 0340-6245
VL - 123
SP - 808
EP - 839
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 8
ER -