Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke

N.A. Terreros*, A.A.E. Bruggeman, H. van Voorst, P.R. Konduri, I.G.H. Jansen, M. Kappelhof, M.L. Tolhuisen, N. Boodt, D.W.J. Dippel, A. van der Lugt, W.H. van Zwam, R.J. van Oostenbrugge, H.B. van der Worp, B.J. Emmer, F.J.A. Meijer, Y.B.W.E.M. Roos, E. van Bavel, H.A. Marquering, C.B.L.M. Majoie

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background A thrombus in the M1 segment of the middle cerebral artery (MCA) can occlude this main stem only or extend into the M1-M2 bifurcation. The occlusion pattern may affect endovascular treatment (EVT) success, as a bifurcated thrombus may be more prone to fragmentation during retrieval.Objective To investigate whether bifurcated thrombus patterns are associated with EVT procedural and clinical outcomes.Methods Occlusion patterns of MCA thrombi on CT angiography from MR CLEAN Registry patients were classified into three groups: main stem occlusion, bifurcation occlusion extending into one M2 branch, and bifurcation occlusion extending into both M2 branches. Procedural parameters, procedural outcomes (reperfusion grade and embolization to new territory), and clinical outcomes (24-48 hour National Institutes of Health Stroke Scale [NIHSSFU] score, change in NIHSS scores between 24 and 48 hours and baseline Delta[NIHSS], and 90-day modified Rankin Scale [mRS] scores) were compared between occlusion patterns.Results We identified 1023 patients with an MCA occlusion of whom 370 (36%) had a main stem occlusion, 151 (15%) a single branch, and 502 (49%) a double branch bifurcation occlusion. There were no statistically significant differences in retrieval method, procedure time, number of retrieval attempts, reperfusion grade, and embolization to new territory between occlusion patterns. Patients with main stem occlusions had lower NIHSSFU scores than patients with single (7 vs 11, p=0.01) or double branch occlusions (7 vs 9, p=0.04). However, there were no statistically significant differences in Delta NIHSS or in 90-day mRS scores.Conclusions In our population, EVT procedural and long-term clinical outcomes were similar for MCA bifurcation occlusions and MCA main stem occlusions.
Original languageEnglish
Pages (from-to)355-362
Number of pages9
JournalJournal of Neurointerventional Surgery
Volume15
Issue number4
Early online date21 Mar 2022
DOIs
Publication statusPublished - Apr 2023

Keywords

  • MIDDLE CEREBRAL-ARTERY
  • MECHANICAL THROMBECTOMY
  • M2 SEGMENT
  • SCALE
  • CLOT

Fingerprint

Dive into the research topics of 'Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this