Abstract

AIMS/HYPOTHESIS: The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS: We included 2,497 participants (mean age 60.0 +/- 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the daily amount of sedentary time, daily number of sedentary breaks and prolonged sedentary bouts (>/=30 min), and the average duration of the sedentary bouts. To determine glucose metabolism status, participants underwent an oral glucose tolerance test. Associations of sedentary behaviour variables with glucose metabolism status and the metabolic syndrome were examined using multinomial logistic regression analyses. RESULTS: Overall, 1,395 (55.9%) participants had normal glucose metabolism, 388 (15.5%) had impaired glucose metabolism and 714 (28.6%) had type 2 diabetes. The odds ratio per additional hour of sedentary time was 1.22 (95% CI 1.13, 1.32) for type 2 diabetes and 1.39 (1.27, 1.53) for the metabolic syndrome. No significant or only weak associations were seen for the number of sedentary breaks, number of prolonged sedentary bouts or average bout duration with either glucose metabolism status or the metabolic syndrome. CONCLUSIONS/INTERPRETATION: An extra hour of sedentary time was associated with a 22% increased odds for type 2 diabetes and a 39% increased odds for the metabolic syndrome. The pattern in which sedentary time was accumulated was weakly associated with the presence of the metabolic syndrome. These results suggest that sedentary behaviour may play a significant role in the development and prevention of type 2 diabetes, although longitudinal studies are needed to confirm our findings.
Original languageEnglish
Pages (from-to)709-718
Number of pages10
JournalDiabetologia
Volume59
Issue number4
DOIs
Publication statusPublished - Apr 2016

Keywords

  • Accelerometry
  • Diabetes mellitus type 2
  • Metabolic syndrome
  • Sedentary bouts
  • Sedentary breaks
  • Sedentary lifestyle
  • Sedentary time
  • PHYSICAL-ACTIVITY
  • CARDIOVASCULAR-DISEASE
  • LIFE-STYLE
  • TIME
  • RISK
  • ADULTS
  • OBESITY
  • BIOMARKERS
  • MARKERS
  • PEOPLE

Cite this

@article{b30aae27256d410f9ba4f3176560fa42,
title = "Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study",
abstract = "AIMS/HYPOTHESIS: The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS: We included 2,497 participants (mean age 60.0 +/- 8.1 years, 52{\%} men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the daily amount of sedentary time, daily number of sedentary breaks and prolonged sedentary bouts (>/=30 min), and the average duration of the sedentary bouts. To determine glucose metabolism status, participants underwent an oral glucose tolerance test. Associations of sedentary behaviour variables with glucose metabolism status and the metabolic syndrome were examined using multinomial logistic regression analyses. RESULTS: Overall, 1,395 (55.9{\%}) participants had normal glucose metabolism, 388 (15.5{\%}) had impaired glucose metabolism and 714 (28.6{\%}) had type 2 diabetes. The odds ratio per additional hour of sedentary time was 1.22 (95{\%} CI 1.13, 1.32) for type 2 diabetes and 1.39 (1.27, 1.53) for the metabolic syndrome. No significant or only weak associations were seen for the number of sedentary breaks, number of prolonged sedentary bouts or average bout duration with either glucose metabolism status or the metabolic syndrome. CONCLUSIONS/INTERPRETATION: An extra hour of sedentary time was associated with a 22{\%} increased odds for type 2 diabetes and a 39{\%} increased odds for the metabolic syndrome. The pattern in which sedentary time was accumulated was weakly associated with the presence of the metabolic syndrome. These results suggest that sedentary behaviour may play a significant role in the development and prevention of type 2 diabetes, although longitudinal studies are needed to confirm our findings.",
keywords = "Accelerometry, Diabetes mellitus type 2, Metabolic syndrome, Sedentary bouts, Sedentary breaks, Sedentary lifestyle, Sedentary time, PHYSICAL-ACTIVITY, CARDIOVASCULAR-DISEASE, LIFE-STYLE, TIME, RISK, ADULTS, OBESITY, BIOMARKERS, MARKERS, PEOPLE",
author = "{van der Berg}, J.D. and C.D. Stehouwer and H. Bosma and {van der Velde}, J.H. and P. Willems and Savelberg, {Hans HCM} and M.T. Schram and Simone Sep and {van der Kallen}, C.J. and R.M. Henry and P.C. Dagnelie and N.C. Schaper and A. Koster",
year = "2016",
month = "4",
doi = "10.1007/s00125-015-3861-8",
language = "English",
volume = "59",
pages = "709--718",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer, Cham",
number = "4",

}

TY - JOUR

T1 - Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study

AU - van der Berg, J.D.

AU - Stehouwer, C.D.

AU - Bosma, H.

AU - van der Velde, J.H.

AU - Willems, P.

AU - Savelberg, Hans HCM

AU - Schram, M.T.

AU - Sep, Simone

AU - van der Kallen, C.J.

AU - Henry, R.M.

AU - Dagnelie, P.C.

AU - Schaper, N.C.

AU - Koster, A.

PY - 2016/4

Y1 - 2016/4

N2 - AIMS/HYPOTHESIS: The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS: We included 2,497 participants (mean age 60.0 +/- 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the daily amount of sedentary time, daily number of sedentary breaks and prolonged sedentary bouts (>/=30 min), and the average duration of the sedentary bouts. To determine glucose metabolism status, participants underwent an oral glucose tolerance test. Associations of sedentary behaviour variables with glucose metabolism status and the metabolic syndrome were examined using multinomial logistic regression analyses. RESULTS: Overall, 1,395 (55.9%) participants had normal glucose metabolism, 388 (15.5%) had impaired glucose metabolism and 714 (28.6%) had type 2 diabetes. The odds ratio per additional hour of sedentary time was 1.22 (95% CI 1.13, 1.32) for type 2 diabetes and 1.39 (1.27, 1.53) for the metabolic syndrome. No significant or only weak associations were seen for the number of sedentary breaks, number of prolonged sedentary bouts or average bout duration with either glucose metabolism status or the metabolic syndrome. CONCLUSIONS/INTERPRETATION: An extra hour of sedentary time was associated with a 22% increased odds for type 2 diabetes and a 39% increased odds for the metabolic syndrome. The pattern in which sedentary time was accumulated was weakly associated with the presence of the metabolic syndrome. These results suggest that sedentary behaviour may play a significant role in the development and prevention of type 2 diabetes, although longitudinal studies are needed to confirm our findings.

AB - AIMS/HYPOTHESIS: The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS: We included 2,497 participants (mean age 60.0 +/- 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the daily amount of sedentary time, daily number of sedentary breaks and prolonged sedentary bouts (>/=30 min), and the average duration of the sedentary bouts. To determine glucose metabolism status, participants underwent an oral glucose tolerance test. Associations of sedentary behaviour variables with glucose metabolism status and the metabolic syndrome were examined using multinomial logistic regression analyses. RESULTS: Overall, 1,395 (55.9%) participants had normal glucose metabolism, 388 (15.5%) had impaired glucose metabolism and 714 (28.6%) had type 2 diabetes. The odds ratio per additional hour of sedentary time was 1.22 (95% CI 1.13, 1.32) for type 2 diabetes and 1.39 (1.27, 1.53) for the metabolic syndrome. No significant or only weak associations were seen for the number of sedentary breaks, number of prolonged sedentary bouts or average bout duration with either glucose metabolism status or the metabolic syndrome. CONCLUSIONS/INTERPRETATION: An extra hour of sedentary time was associated with a 22% increased odds for type 2 diabetes and a 39% increased odds for the metabolic syndrome. The pattern in which sedentary time was accumulated was weakly associated with the presence of the metabolic syndrome. These results suggest that sedentary behaviour may play a significant role in the development and prevention of type 2 diabetes, although longitudinal studies are needed to confirm our findings.

KW - Accelerometry

KW - Diabetes mellitus type 2

KW - Metabolic syndrome

KW - Sedentary bouts

KW - Sedentary breaks

KW - Sedentary lifestyle

KW - Sedentary time

KW - PHYSICAL-ACTIVITY

KW - CARDIOVASCULAR-DISEASE

KW - LIFE-STYLE

KW - TIME

KW - RISK

KW - ADULTS

KW - OBESITY

KW - BIOMARKERS

KW - MARKERS

KW - PEOPLE

U2 - 10.1007/s00125-015-3861-8

DO - 10.1007/s00125-015-3861-8

M3 - Article

VL - 59

SP - 709

EP - 718

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -