Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

I. Reinders*, A. J. van Ballegooijen, M. Visser, A. K. Elshorbagy, H. Refsum, R. M. A. Henry, J. M. Dekker, G. Nijpels, C. D. A. Stehouwer, I. A. Brouwer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up. SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6 +/- 6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles assayed by gas liquid chromatography with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate. RESULTS: In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend
Original languageEnglish
Pages (from-to)1277-1283
JournalEuropean Journal of Clinical Nutrition
Issue number12
Publication statusPublished - Dec 2013


  • polyunsaturated fatty acids
  • elderly
  • epidemiology
  • echocardiography
  • systolic function

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