Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

I. Reinders; A. J. van Ballegooijen; M. Visser; A. K. Elshorbagy; H. Refsum; R. M. A. Henry; J. M. Dekker; G. Nijpels; C. D. A. Stehouwer; I. A. Brouwer

doi:10.1038/ejcn.2013.167

Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

I. Reinders^*, A. J. van Ballegooijen, M. Visser, A. K. Elshorbagy, H. Refsum, R. M. A. Henry, J. M. Dekker, G. Nijpels, C. D. A. Stehouwer, I. A. Brouwer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up. SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6 +/- 6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles assayed by gas liquid chromatography with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate. RESULTS: In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend

Original language	English
Pages (from-to)	1277-1283
Journal	European Journal of Clinical Nutrition
Volume	67
Issue number	12
DOIs	https://doi.org/10.1038/ejcn.2013.167
Publication status	Published - Dec 2013

Keywords

polyunsaturated fatty acids
elderly
epidemiology
echocardiography
systolic function

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10.1038/ejcn.2013.167

Cite this

Reinders, I., van Ballegooijen, A. J., Visser, M., Elshorbagy, A. K., Refsum, H., Henry, R. M. A., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., & Brouwer, I. A. (2013). Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. European Journal of Clinical Nutrition, 67(12), 1277-1283. https://doi.org/10.1038/ejcn.2013.167

@article{4477542366ba47719182512d5a3708ad,

title = "Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study",

abstract = "BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up. SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6 +/- 6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles assayed by gas liquid chromatography with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate. RESULTS: In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend ",

keywords = "polyunsaturated fatty acids, elderly, epidemiology, echocardiography, systolic function",

author = "I. Reinders and {van Ballegooijen}, {A. J.} and M. Visser and Elshorbagy, {A. K.} and H. Refsum and Henry, {R. M. A.} and Dekker, {J. M.} and G. Nijpels and Stehouwer, {C. D. A.} and Brouwer, {I. A.}",

year = "2013",

month = dec,

doi = "10.1038/ejcn.2013.167",

language = "English",

volume = "67",

pages = "1277--1283",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

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Reinders, I, van Ballegooijen, AJ, Visser, M, Elshorbagy, AK, Refsum, H, Henry, RMA, Dekker, JM, Nijpels, G, Stehouwer, CDA & Brouwer, IA 2013, 'Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study', European Journal of Clinical Nutrition, vol. 67, no. 12, pp. 1277-1283. https://doi.org/10.1038/ejcn.2013.167

TY - JOUR

T1 - Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

AU - Reinders, I.

AU - van Ballegooijen, A. J.

AU - Visser, M.

AU - Elshorbagy, A. K.

AU - Refsum, H.

AU - Henry, R. M. A.

AU - Dekker, J. M.

AU - Nijpels, G.

AU - Stehouwer, C. D. A.

AU - Brouwer, I. A.

PY - 2013/12

Y1 - 2013/12

N2 - BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up. SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6 +/- 6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles assayed by gas liquid chromatography with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate. RESULTS: In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend

AB - BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up. SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6 +/- 6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles assayed by gas liquid chromatography with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate. RESULTS: In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend

KW - polyunsaturated fatty acids

KW - elderly

KW - epidemiology

KW - echocardiography

KW - systolic function

U2 - 10.1038/ejcn.2013.167

DO - 10.1038/ejcn.2013.167

M3 - Article

C2 - 24084512

SN - 0954-3007

VL - 67

SP - 1277

EP - 1283

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 12

ER -