TY - JOUR
T1 - Associations of inner retinal layers with risk of incident dementia
T2 - An individual participant data analysis of four prospective cohort studies
AU - van der Heide, Frank C T
AU - Khawaja, Anthony
AU - Berendschot, Tos T J M
AU - Littlejohns, Thomas J
AU - Kuźma, Elżbieta
AU - Luben, Robert
AU - Patel, Praveen J
AU - Foster, Paul J
AU - Webers, Carroll
AU - Kroon, Bram
AU - van der Kallen, Carla
AU - van Dongen, Martinus
AU - Eussen, Simone
AU - Schalkwijk, Casper
AU - Bosma, Hans
AU - Koehler, Sebastian
AU - Schram, Miranda
AU - Blokland, Gabriëlla
AU - Linden, David
AU - Wesselius, Anke
AU - Maastricht Study Consortium
AU - Bertelsen, Geir
AU - von Hanno, Therese
AU - Johnsen, Bente
AU - Schirmer, Henrik
AU - Rebouças, Sara C L
AU - Grasset, Leslie
AU - Delcourt, Cécile
AU - Helmer, Catherine
AU - UK Biobank Eye & Vision Consortium
AU - European Eye Epidemiology (E3) Consortium
AU - Stehouwer, Coen D A
N1 - © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years).RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes.DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.
AB - INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years).RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes.DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.
U2 - 10.1002/alz.13167
DO - 10.1002/alz.13167
M3 - Article
C2 - 37551793
SN - 1552-5260
VL - 20
SP - 211
EP - 220
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 1
M1 - 13167
ER -