TY - JOUR
T1 - Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2
T2 - the BRCA1 and BRCA2 Cohort Consortium
AU - Kast, Karin
AU - John, Esther M
AU - Hopper, John L
AU - Andrieu, Nadine
AU - Noguès, Catherine
AU - Mouret-Fourme, Emmanuelle
AU - Lasset, Christine
AU - Fricker, Jean-Pierre
AU - Berthet, Pascaline
AU - Mari, Véronique
AU - Salle, Lucie
AU - Schmidt, Marjanka K
AU - Ausems, Margreet G E M
AU - Garcia, Encarnacion B Gomez
AU - van de Beek, Irma
AU - Wevers, Marijke R
AU - Evans, D Gareth
AU - Tischkowitz, Marc
AU - Lalloo, Fiona
AU - Cook, Jackie
AU - Izatt, Louise
AU - Tripathi, Vishakha
AU - Snape, Katie
AU - Musgrave, Hannah
AU - Sharif, Saba
AU - Murray, Jennie
AU - Colonna, Sarah V
AU - Andrulis, Irene L
AU - Daly, Mary B
AU - Southey, Melissa C
AU - de la Hoya, Miguel
AU - Osorio, Ana
AU - Foretova, Lenka
AU - Berkova, Dita
AU - Gerdes, Anne-Marie
AU - Olah, Edith
AU - Jakubowska, Anna
AU - Singer, Christian F
AU - Tan, Yen
AU - Augustinsson, Annelie
AU - Rantala, Johanna
AU - Simard, Jacques
AU - Schmutzler, Rita K
AU - Milne, Roger L
AU - Phillips, Kelly-Anne
AU - Terry, Mary Beth
AU - Goldgar, David
AU - van Leeuwen, Flora E
AU - Mooij, Thea M
AU - Antoniou, Antonis C
AU - EMBRACE Collaborators
AU - Gomez Garcia, Encarna B.
N1 - © 2023. The Author(s).
PY - 2023/6/20
Y1 - 2023/6/20
N2 - INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively).CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.
AB - INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively).CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.
KW - Adult
KW - Female
KW - Humans
KW - Body Mass Index
KW - Genes, BRCA2
KW - BRCA1 Protein/genetics
KW - Breast Neoplasms/epidemiology
KW - BRCA2 Protein/genetics
KW - Risk
KW - Retrospective Studies
KW - Weight Gain/genetics
KW - Heterozygote
KW - Genetic Predisposition to Disease
U2 - 10.1186/s13058-023-01673-w
DO - 10.1186/s13058-023-01673-w
M3 - Article
C2 - 37340476
SN - 1465-5411
VL - 25
SP - 72
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
ER -