Association of Trunk/Leg Fat Mass Ratio with Low-Density Lipoproteins-Cholesterol and Triglycerides Concentration in Children and Adolescents: A Cross-Sectional, Retrospective Study

I. Duran*, K. Martakis, E. Alberg, M. Jackels, K.R. Ewert, E. Schoenau

*Corresponding author for this work

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2 Citations (Web of Science)

Abstract

Background:Increased central (or abdominal) fat mass has been associated with cardiometabolic risk factors such as high low-density lipoproteins (LDL)-cholesterol or triglycerides (TG) concentration in children. Objectives:To generate pediatric reference centiles for trunk/leg fat mass ratio (T2L) (assessed by dual-energy X-ray absorptiometry [DXA]) and to evaluate the association of LDL-cholesterol and TG concentrations with T2L in children and adolescents.Methods:Data of the National Health and Nutrition Examination Survey (1999-2004) were used to determine total and regional fat mass by DXA of the participants (aged 8-19 years) who had also an examination of LDL-cholesterol and TG concentrations. Fat mass was assessed by DXA-determined fat mass index (FMI). Central fat mass was quantified by T2L. Results:The DXA results of 6538 children and adolescents (2629 females) were used to generate reference centiles for T2L. In girls, T2L was significantly associated with high LDL-cholesterol and TG concentration (odds ratio [OR] adjusted to FMI 1.69), (95% confidence interval [CI] 1.20-2.40), and 1.45 (95% CI 1.11-1.91,p = 0.003 andp = 0.008). In boys, T2L was significantly associated only with high TG concentration (OR adjusted to FMI 1.81 [95% CI 1.52-2.19,p < 0.001]). Conclusions:A central fat distribution seemed to be an independent risk factor for high TG concentrations in children and for high LDL-cholesterol only in girls. The first ethnicity-specific, pediatric reference centiles for T2L were presented.

Original languageEnglish
Pages (from-to)428-439
Number of pages12
JournalChildhood obesity
Volume16
Issue number6
DOIs
Publication statusPublished - 1 Sept 2020

Keywords

  • abdominal fat
  • body-fat
  • cardiometabolic risk-factors
  • central adiposity
  • cholesterol concentration
  • indian children
  • insulin sensitivity
  • leg fat mass ratio
  • low-density lipoproteins
  • metabolic risk
  • reference centiles
  • resistance exercise
  • sex-differences
  • to-height ratio
  • triglycerides concentration
  • trunk
  • waist circumference
  • INDIAN CHILDREN
  • CARDIOMETABOLIC RISK-FACTORS
  • BODY-FAT
  • RESISTANCE EXERCISE
  • TO-HEIGHT RATIO
  • ABDOMINAL FAT
  • INSULIN SENSITIVITY
  • WAIST CIRCUMFERENCE
  • METABOLIC RISK
  • SEX-DIFFERENCES

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