TY - JOUR
T1 - Association of serum fetuin-A levels with mortality in dialysis patients.
AU - Hermans, M.M.
AU - Brandenburg, V.
AU - Ketteler, M.
AU - Kooman, J.P.
AU - van der Sande, F.M.
AU - Boeschoten, E.W.
AU - Leunissen, K.M.L.
AU - Krediet, R.T.
AU - Dekker, F.W.
AU - Netherlands cooperative study on the adequacy of Dialysis, NECOSAD
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients.
AB - Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients.
U2 - 10.1038/sj.ki.5002178
DO - 10.1038/sj.ki.5002178
M3 - Article
SN - 0085-2538
VL - 72
SP - 202
EP - 207
JO - Kidney International
JF - Kidney International
IS - 2
ER -