TY - JOUR
T1 - Association of PM2.5 mass and its components with ovarian reserve in a northern peninsular province, China
T2 - The critical exposure period and components
AU - Pang, Lihong
AU - Jiang, Mingdong
AU - Sui, Xinlei
AU - Dou, Yunde
AU - Yu, Wenhao
AU - Huxley, Rachel
AU - Saldiva, Paulo
AU - Hu, Jingmei
AU - Schikowski, Tamara
AU - Krafft, Thomas
AU - Gao, Panjun
AU - Zhao, Yueran
AU - Zhao, Han
AU - Zhao, Qi
AU - Chen, Zi-Jiang
PY - 2023/10/6
Y1 - 2023/10/6
N2 - BACKGROUND: A possible role of PM components on ovarian reserve has not been adequately unexplored. OBJECTIVE: To evaluate the association between PM components and women' ovarian reserve over critical exposure periods in northern China, where the level of air pollution is among the nation's highest. METHODS: We included 15,102 women with serum anti-Müllerian hormone (AMH) measurements from the Center for Reproductive Medicine of Shandong University during 2015-2019. Concentrations of PM and its five major components (0.1° × 0.1°), including sulfate, nitrate, ammonium, organic matter, and black carbon, were assigned to each residential address. Multivariable linear mixed effect models combined with constituent-residual models were performed to estimate the effect sizes of essential components over six short- to long-term exposure periods. RESULTS: The strength of association was stronger during the process from primary to small antral follicle compared with other longer windows. For every interquartile range increase in PM mass was associated with - 8.7% (95%CI: -12.3%, -4.9%) change in AMH and the effect size was greatest for sulfate. Women with the lower level of attained education and those living inland were more susceptible compared with other population subgroups. CONCLUSION: Exposure to specific components of air pollution during critical exposure windows is associated with a decline in ovarian reserve. These data add to the growing body of evidence that environmental factors have adverse effects on reproductive health, particularly for vulnerable population subgroups.
AB - BACKGROUND: A possible role of PM components on ovarian reserve has not been adequately unexplored. OBJECTIVE: To evaluate the association between PM components and women' ovarian reserve over critical exposure periods in northern China, where the level of air pollution is among the nation's highest. METHODS: We included 15,102 women with serum anti-Müllerian hormone (AMH) measurements from the Center for Reproductive Medicine of Shandong University during 2015-2019. Concentrations of PM and its five major components (0.1° × 0.1°), including sulfate, nitrate, ammonium, organic matter, and black carbon, were assigned to each residential address. Multivariable linear mixed effect models combined with constituent-residual models were performed to estimate the effect sizes of essential components over six short- to long-term exposure periods. RESULTS: The strength of association was stronger during the process from primary to small antral follicle compared with other longer windows. For every interquartile range increase in PM mass was associated with - 8.7% (95%CI: -12.3%, -4.9%) change in AMH and the effect size was greatest for sulfate. Women with the lower level of attained education and those living inland were more susceptible compared with other population subgroups. CONCLUSION: Exposure to specific components of air pollution during critical exposure windows is associated with a decline in ovarian reserve. These data add to the growing body of evidence that environmental factors have adverse effects on reproductive health, particularly for vulnerable population subgroups.
KW - Anti-Müllerian hormone
KW - Exposure period
KW - Ovarian reserve
KW - PM(2.5) components
U2 - 10.1016/j.jhazmat.2023.132735
DO - 10.1016/j.jhazmat.2023.132735
M3 - Article
SN - 1873-3336
VL - 462
JO - Journal of hazardous materials
JF - Journal of hazardous materials
IS - 1
M1 - 132735
ER -