TY - JOUR
T1 - Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque
T2 - Individual Participant Data Meta-Analysis of 20 Prospective Studies
AU - Tschiderer, Lena
AU - Seekircher, Lisa
AU - Izzo, Raffaele
AU - Mancusi, Costantino
AU - Manzi, Maria V
AU - Baldassarre, Damiano
AU - Amato, Mauro
AU - Tremoli, Elena
AU - Veglia, Fabrizio
AU - Tuomainen, Tomi-Pekka
AU - Kauhanen, Jussi
AU - Voutilainen, Ari
AU - Iglseder, Bernhard
AU - Lind, Lars
AU - Rundek, Tatjana
AU - Desvarieux, Moise
AU - Kato, Akihiko
AU - de Groot, Eric
AU - Aşçi, Gülay
AU - Ok, Ercan
AU - Agewall, Stefan
AU - Beulens, Joline W J
AU - Byrne, Christopher D
AU - Calder, Philip C
AU - Gerstein, Hertzel C
AU - Gresele, Paolo
AU - Klingenschmid, Gerhard
AU - Nagai, Michiaki
AU - Olsen, Michael H
AU - Parraga, Grace
AU - Safarova, Maya S
AU - Sattar, Naveed
AU - Skilton, Michael
AU - Stehouwer, Coen D A
AU - Uthoff, Heiko
AU - van Agtmael, Michiel A
AU - van der Heijden, Amber A
AU - Zozulińska-Ziółkiewicz, Dorota A
AU - Park, Hyun-Woong
AU - Lee, Moo-Sik
AU - Bae, Jang-Ho
AU - Beloqui, Oscar
AU - Landecho, Manuel F
AU - Plichart, Matthieu
AU - Ducimetiere, Pierre
AU - Empana, Jean Philippe
AU - Bokemark, Lena
AU - Bergström, Göran
AU - Schmidt, Caroline
AU - Liu, Jing
AU - Willeit, P.
AU - Proof‐ATHERO Study Group
PY - 2023/6/20
Y1 - 2023/6/20
N2 - Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
AB - Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
KW - Humans
KW - Female
KW - Middle Aged
KW - Male
KW - Carotid Intima-Media Thickness
KW - Prospective Studies
KW - Risk Factors
KW - Plaque, Atherosclerotic
KW - Carotid Artery, Common/diagnostic imaging
KW - Carotid Artery Diseases/diagnostic imaging
U2 - 10.1161/JAHA.122.027657
DO - 10.1161/JAHA.122.027657
M3 - Article
C2 - 37301757
SN - 2047-9980
VL - 12
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 12
M1 - e027657
ER -