Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study

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Abstract

Objective:

Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status.

Methods:

A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 +/- 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus.

Results:

Higher uric acid (per SD of 74 mu mol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [beta = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [beta = -0.633 (95% confidence interval -1.099, -0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P <0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex.

Conclusion:

Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40-75 years without and with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)1642-1650
Number of pages9
JournalJournal of Hypertension
Volume33
Issue number8
DOIs
Publication statusPublished - Aug 2015

Keywords

  • PULSE-WAVE VELOCITY
  • GLOMERULAR-FILTRATION-RATE
  • EXPERT CONSENSUS DOCUMENT
  • MUSCLE-CELL PROLIFERATION
  • ARTERIAL STIFFNESS
  • HYPERTENSIVE PATIENTS
  • SUBCLINICAL ATHEROSCLEROSIS
  • CARDIOVASCULAR-DISEASE
  • URATE TRANSPORTER
  • BLOOD-PRESSURE

Cite this

@article{1c825781528a4d6d82e8c1ffe56851cc,
title = "Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study",
abstract = "Objective:Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status.Methods:A cross-sectional study was performed in 614 adults [52.6{\%} men; mean age 58.7 +/- 8.5 years; 23.2{\%} type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus.Results:Higher uric acid (per SD of 74 mu mol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [beta = 0.216 (95{\%} confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [beta = -0.633 (95{\%} confidence interval -1.099, -0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P <0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex.Conclusion:Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40-75 years without and with type 2 diabetes mellitus.",
keywords = "PULSE-WAVE VELOCITY, GLOMERULAR-FILTRATION-RATE, EXPERT CONSENSUS DOCUMENT, MUSCLE-CELL PROLIFERATION, ARTERIAL STIFFNESS, HYPERTENSIVE PATIENTS, SUBCLINICAL ATHEROSCLEROSIS, CARDIOVASCULAR-DISEASE, URATE TRANSPORTER, BLOOD-PRESSURE",
author = "J.M.A. Wijnands and A. Boonen and {van Sloten}, T.T. and M.T. Schram and S.J.S. Sep and A. Koster and {van der Kallen}, C.J.H. and R.M.A. Henry and P.C. Dagnelie and C.D.A. Stehouwer and {van der Linden}, S. and I.C.W. Arts",
year = "2015",
month = "8",
doi = "10.1097/HJH.0000000000000593",
language = "English",
volume = "33",
pages = "1642--1650",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "8",

}

TY - JOUR

T1 - Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study

AU - Wijnands, J.M.A.

AU - Boonen, A.

AU - van Sloten, T.T.

AU - Schram, M.T.

AU - Sep, S.J.S.

AU - Koster, A.

AU - van der Kallen, C.J.H.

AU - Henry, R.M.A.

AU - Dagnelie, P.C.

AU - Stehouwer, C.D.A.

AU - van der Linden, S.

AU - Arts, I.C.W.

PY - 2015/8

Y1 - 2015/8

N2 - Objective:Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status.Methods:A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 +/- 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus.Results:Higher uric acid (per SD of 74 mu mol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [beta = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [beta = -0.633 (95% confidence interval -1.099, -0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P <0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex.Conclusion:Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40-75 years without and with type 2 diabetes mellitus.

AB - Objective:Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status.Methods:A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 +/- 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus.Results:Higher uric acid (per SD of 74 mu mol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [beta = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [beta = -0.633 (95% confidence interval -1.099, -0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P <0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex.Conclusion:Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40-75 years without and with type 2 diabetes mellitus.

KW - PULSE-WAVE VELOCITY

KW - GLOMERULAR-FILTRATION-RATE

KW - EXPERT CONSENSUS DOCUMENT

KW - MUSCLE-CELL PROLIFERATION

KW - ARTERIAL STIFFNESS

KW - HYPERTENSIVE PATIENTS

KW - SUBCLINICAL ATHEROSCLEROSIS

KW - CARDIOVASCULAR-DISEASE

KW - URATE TRANSPORTER

KW - BLOOD-PRESSURE

U2 - 10.1097/HJH.0000000000000593

DO - 10.1097/HJH.0000000000000593

M3 - Article

VL - 33

SP - 1642

EP - 1650

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 8

ER -