Abstract

The relationship between exhaled inflammatory markers and asthma control in children is unclear. To explore the association between inflammatory markers in exhaled breath (fractional nitric oxide (FeNO), volatile organic compounds (VOCs), cytokines/chemokines) and asthma control. To assess whether exhaled inflammatory markers are able to discriminate between children with persistently controlled/uncontrolled asthma. 96 asthmatic children were followed-up in a one-year observational study. Every 2 months, the following parameters were assessed: asthma control, FeNO, lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), exhaled VOCs, and cytokines/chemokines in exhaled breath condensate (EBC). Random Forest was used to analyse the relationship between exhaled inflammatory markers and asthma control. For each model, patients were randomly selected for a training set and validation set. To assess the accuracy of the classification models, receiver operating characteristic-curves (ROC-curves) were generated. No significant association was found between the exhaled inflammatory markers (FeNO, markers in EBC, VOCs) and asthma control (area under the ROC-curve 49%). However, 15 exhaled VOCs could discriminate between subgroups of children with persistently controlled and uncontrolled asthma during all clinical visits (area under the ROC-curve 86%). Adding FeNO and markers in EBC to this model, did not lead to a more accurate classification (area under the ROC-curve 87%). There was no association between exhaled inflammatory markers and asthma control in children. However, children with persistently controlled or uncontrolled asthma during the 12 month study period could be discriminated by a set of VOCs.
Original languageEnglish
Article number016014
Number of pages9
JournalJournal of Breath Research
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 2016

Keywords

  • asthma
  • exhaled breath analysis
  • volatile organic compounds
  • FeNO
  • exhaled breath condensate
  • asthma control
  • prospective observational study
  • VOLATILE ORGANIC-COMPOUNDS
  • BREATH CONDENSATE
  • CHILDHOOD ASTHMA
  • NITRIC-OXIDE
  • AIRWAY INFLAMMATION
  • LUNG-FUNCTION
  • EXACERBATIONS
  • BIOMARKERS
  • SYMPTOMS

Cite this

@article{ce87e9cb8c914ef1901f0582f3cb2b59,
title = "Association between exhaled inflammatory markers and asthma control in children",
abstract = "The relationship between exhaled inflammatory markers and asthma control in children is unclear. To explore the association between inflammatory markers in exhaled breath (fractional nitric oxide (FeNO), volatile organic compounds (VOCs), cytokines/chemokines) and asthma control. To assess whether exhaled inflammatory markers are able to discriminate between children with persistently controlled/uncontrolled asthma. 96 asthmatic children were followed-up in a one-year observational study. Every 2 months, the following parameters were assessed: asthma control, FeNO, lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), exhaled VOCs, and cytokines/chemokines in exhaled breath condensate (EBC). Random Forest was used to analyse the relationship between exhaled inflammatory markers and asthma control. For each model, patients were randomly selected for a training set and validation set. To assess the accuracy of the classification models, receiver operating characteristic-curves (ROC-curves) were generated. No significant association was found between the exhaled inflammatory markers (FeNO, markers in EBC, VOCs) and asthma control (area under the ROC-curve 49{\%}). However, 15 exhaled VOCs could discriminate between subgroups of children with persistently controlled and uncontrolled asthma during all clinical visits (area under the ROC-curve 86{\%}). Adding FeNO and markers in EBC to this model, did not lead to a more accurate classification (area under the ROC-curve 87{\%}). There was no association between exhaled inflammatory markers and asthma control in children. However, children with persistently controlled or uncontrolled asthma during the 12 month study period could be discriminated by a set of VOCs.",
keywords = "asthma, exhaled breath analysis, volatile organic compounds, FeNO, exhaled breath condensate, asthma control, prospective observational study, VOLATILE ORGANIC-COMPOUNDS, BREATH CONDENSATE, CHILDHOOD ASTHMA, NITRIC-OXIDE, AIRWAY INFLAMMATION, LUNG-FUNCTION, EXACERBATIONS, BIOMARKERS, SYMPTOMS",
author = "{van Vliet}, Dillys and A. Smolinska and Quirijn J{\"o}bsis and P.P. Rosias and J.W.M. Muris and J.W. Dallinga and {van Schooten}, Frederik and E. Dompeling",
year = "2016",
month = "3",
doi = "10.1088/1752-7155/10/1/016014",
language = "English",
volume = "10",
journal = "Journal of Breath Research",
issn = "1752-7155",
publisher = "IOP Publishing Ltd.",
number = "1",

}

Association between exhaled inflammatory markers and asthma control in children. / van Vliet, Dillys; Smolinska, A.; Jöbsis, Quirijn; Rosias, P.P.; Muris, J.W.M.; Dallinga, J.W.; van Schooten, Frederik; Dompeling, E.

In: Journal of Breath Research, Vol. 10, No. 1, 016014, 03.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association between exhaled inflammatory markers and asthma control in children

AU - van Vliet, Dillys

AU - Smolinska, A.

AU - Jöbsis, Quirijn

AU - Rosias, P.P.

AU - Muris, J.W.M.

AU - Dallinga, J.W.

AU - van Schooten, Frederik

AU - Dompeling, E.

PY - 2016/3

Y1 - 2016/3

N2 - The relationship between exhaled inflammatory markers and asthma control in children is unclear. To explore the association between inflammatory markers in exhaled breath (fractional nitric oxide (FeNO), volatile organic compounds (VOCs), cytokines/chemokines) and asthma control. To assess whether exhaled inflammatory markers are able to discriminate between children with persistently controlled/uncontrolled asthma. 96 asthmatic children were followed-up in a one-year observational study. Every 2 months, the following parameters were assessed: asthma control, FeNO, lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), exhaled VOCs, and cytokines/chemokines in exhaled breath condensate (EBC). Random Forest was used to analyse the relationship between exhaled inflammatory markers and asthma control. For each model, patients were randomly selected for a training set and validation set. To assess the accuracy of the classification models, receiver operating characteristic-curves (ROC-curves) were generated. No significant association was found between the exhaled inflammatory markers (FeNO, markers in EBC, VOCs) and asthma control (area under the ROC-curve 49%). However, 15 exhaled VOCs could discriminate between subgroups of children with persistently controlled and uncontrolled asthma during all clinical visits (area under the ROC-curve 86%). Adding FeNO and markers in EBC to this model, did not lead to a more accurate classification (area under the ROC-curve 87%). There was no association between exhaled inflammatory markers and asthma control in children. However, children with persistently controlled or uncontrolled asthma during the 12 month study period could be discriminated by a set of VOCs.

AB - The relationship between exhaled inflammatory markers and asthma control in children is unclear. To explore the association between inflammatory markers in exhaled breath (fractional nitric oxide (FeNO), volatile organic compounds (VOCs), cytokines/chemokines) and asthma control. To assess whether exhaled inflammatory markers are able to discriminate between children with persistently controlled/uncontrolled asthma. 96 asthmatic children were followed-up in a one-year observational study. Every 2 months, the following parameters were assessed: asthma control, FeNO, lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), exhaled VOCs, and cytokines/chemokines in exhaled breath condensate (EBC). Random Forest was used to analyse the relationship between exhaled inflammatory markers and asthma control. For each model, patients were randomly selected for a training set and validation set. To assess the accuracy of the classification models, receiver operating characteristic-curves (ROC-curves) were generated. No significant association was found between the exhaled inflammatory markers (FeNO, markers in EBC, VOCs) and asthma control (area under the ROC-curve 49%). However, 15 exhaled VOCs could discriminate between subgroups of children with persistently controlled and uncontrolled asthma during all clinical visits (area under the ROC-curve 86%). Adding FeNO and markers in EBC to this model, did not lead to a more accurate classification (area under the ROC-curve 87%). There was no association between exhaled inflammatory markers and asthma control in children. However, children with persistently controlled or uncontrolled asthma during the 12 month study period could be discriminated by a set of VOCs.

KW - asthma

KW - exhaled breath analysis

KW - volatile organic compounds

KW - FeNO

KW - exhaled breath condensate

KW - asthma control

KW - prospective observational study

KW - VOLATILE ORGANIC-COMPOUNDS

KW - BREATH CONDENSATE

KW - CHILDHOOD ASTHMA

KW - NITRIC-OXIDE

KW - AIRWAY INFLAMMATION

KW - LUNG-FUNCTION

KW - EXACERBATIONS

KW - BIOMARKERS

KW - SYMPTOMS

U2 - 10.1088/1752-7155/10/1/016014

DO - 10.1088/1752-7155/10/1/016014

M3 - Article

VL - 10

JO - Journal of Breath Research

JF - Journal of Breath Research

SN - 1752-7155

IS - 1

M1 - 016014

ER -