Appropriateness of early management of newly diagnosed Crohn's disease in a European population-based cohort

Pascal Juillerat*, Valerie Pittet, Christian Mottet, Christian Felley, Jean-Jacques Gonvers, John-Paul Vader, Bernard Burnand, Florian Froehlich, Frank L. Wolters, Reinhold W. Stockbrugger, Pierre Michetti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective. The European Panel on the Appropriateness of Crohn's disease Therapy (EPACT) has developed appropriateness criteria. We have applied these criteria retrospectively to the population-based inception cohort of Crohn's disease (CD) patients of the European Collaborative Study Group on Inflammatory Bowel Disease (EC-IBD). Material and methods. A total of 426 diagnosed CD patients from 13 European centers were enrolled at the time of diagnosis (first flare, naive patients). We used the EPACT definitions to identify 247 patients with active luminal CD. We then assessed the appropriateness of the initial drug prescription according to the EPACT criteria. Results. Among the cohort patients 163 suffered from mild-to-moderate CD and 84 from severe CD. Among the mild-to-moderate disease group, 96 patients (59%) received an appropriate treatment, whereas for 66 patients (40%) the treatment was uncertain and in one case (1%) inappropriate. Among the severe disease group, 86% were treated medically and 14% required surgery. 59 (70%) were appropriately treated, whereas for one patient (1%) the procedure was considered uncertain and for 24 patients (29%) inappropriate. Conclusion. Initial treatment was appropriate in the majority of cases for non-complicated luminal CD. Inappropriate or uncertain treatment was given in a significant minority of patients, with an increased potential risk of adverse events.
Original languageEnglish
Pages (from-to)1449-1456
JournalScandinavian Journal of Gastroenterology
Issue number12
Publication statusPublished - Dec 2010


  • Appropriateness
  • Crohn's disease
  • inflammatory bowel disease
  • RAND appropriateness method
  • therapy


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