Applying novel identication protocols to Markov models of INa

Michael Clerx; Pieter Collins; Paul Volders

Applying novel identication protocols to Markov models of INa

Michael Clerx^*, Pieter Collins, Paul Volders

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

Abstract

Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.

Original language	English
Title of host publication	COMPUTING IN CARDIOLOGY CONFERENCE. 2015. (CinC 2015)
Subtitle of host publication	Proceedings of the 42nd Annual Conference on Computing in Cardiology
Pages	889-892
Number of pages	4
Publication status	Published - 2015
Event	Computing in Cardiology - Nice, France Duration: 6 Sept 2015 → 9 Sept 2015

Conference

Conference	Computing in Cardiology
Abbreviated title	CinC
Country/Territory	France
City	Nice
Period	6/09/15 → 9/09/15

Cite this

@inproceedings{7f28d4809a3340ccb99db1924f1718e2,

title = "Applying novel identication protocols to Markov models of INa",

abstract = "Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.",

author = "Michael Clerx and Pieter Collins and Paul Volders",

year = "2015",

language = "English",

isbn = "9781509006601",

pages = "889--892",

booktitle = "COMPUTING IN CARDIOLOGY CONFERENCE. 2015. (CinC 2015)",

note = "Computing in Cardiology, CinC ; Conference date: 06-09-2015 Through 09-09-2015",

}

Applying novel identication protocols to Markov models of INa. / Clerx, Michael; Collins, Pieter ; Volders, Paul.
COMPUTING IN CARDIOLOGY CONFERENCE. 2015. (CinC 2015): Proceedings of the 42nd Annual Conference on Computing in Cardiology. 2015. p. 889-892.

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - Applying novel identication protocols to Markov models of INa

AU - Clerx, Michael

AU - Collins, Pieter

AU - Volders, Paul

PY - 2015

Y1 - 2015

N2 - Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.

AB - Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.

M3 - Conference article in proceeding

SN - 9781509006601

SP - 889

EP - 892

BT - COMPUTING IN CARDIOLOGY CONFERENCE. 2015. (CinC 2015)

T2 - Computing in Cardiology

Y2 - 6 September 2015 through 9 September 2015

ER -