Applying novel identication protocols to Markov models of INa

Michael Clerx*, Pieter Collins, Paul Volders

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

Abstract

Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.
Original languageEnglish
Title of host publicationCOMPUTING IN CARDIOLOGY CONFERENCE. 2015. (CinC 2015)
Subtitle of host publicationProceedings of the 42nd Annual Conference on Computing in Cardiology
Pages889-892
Number of pages4
Publication statusPublished - 2015
EventComputing in Cardiology - Nice, France
Duration: 6 Sep 20159 Sep 2015

Conference

ConferenceComputing in Cardiology
Abbreviated titleCinC
CountryFrance
CityNice
Period6/09/159/09/15

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