Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Pieter Van de Vijver; Liesbeth Scheer; Judy van Beijnum; Arjan Griffioen; Tilman M. Hackeng

doi:10.1039/c2cc34956f

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Pieter Van de Vijver^*, Liesbeth Scheer, Judy van Beijnum, Arjan Griffioen, Tilman M. Hackeng

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

Original language	English
Pages (from-to)	9403-9405
Journal	Chemical Communications
Volume	48
Issue number	75
DOIs	https://doi.org/10.1039/c2cc34956f
Publication status	Published - 2012

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10.1039/c2cc34956f

Cite this

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title = "Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain",

abstract = "The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.",

author = "{Van de Vijver}, Pieter and Liesbeth Scheer and {van Beijnum}, Judy and Arjan Griffioen and Hackeng, {Tilman M.}",

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AU - Van de Vijver, Pieter

AU - Scheer, Liesbeth

AU - van Beijnum, Judy

AU - Griffioen, Arjan

AU - Hackeng, Tilman M.

PY - 2012

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AB - The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

U2 - 10.1039/c2cc34956f

DO - 10.1039/c2cc34956f

M3 - Article

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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