Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Pieter Van de Vijver*, Liesbeth Scheer, Judy van Beijnum, Arjan Griffioen, Tilman M. Hackeng

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.
Original languageEnglish
Pages (from-to)9403-9405
JournalChemical Communications
Issue number75
Publication statusPublished - 2012

Cite this