Antimicrobial resistance in Escherichia coli and Pseudomonas aeruginosa from Intensive Care Units in The Netherlands, 1998-2005

G.J.A.P.M. Oudhuis, A. Verbon, J.A.A.; Hoogkamp-Korstanje, E.E. Stobberingh

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In 1998, a nationwide surveillance of antibiotic resistance among Escherichia coli and Pseudomonas aeruginosa isolates of patients from 14 Intensive Care Units in The Netherlands was initiated. Minimal inhibitory concentrations (MICs) of broad-spectrum penicillins with and without P-lactamase inhibitors, cephalosporins, aminoglycosides and fluoroquinolones were determined by a broth microdilution method. An increase in percentages of resistance of E. coli and P. aeruginosa to most antibiotics tested was observed, but rates were still lower than those described in other countries. For E. coli, resistance to amoxicillin was fairly stable at 44% until 2004 and increased to 56% (P = 0.01) in 2005. Similarly, piperacillin had a resistance rate of ca. 11% until 2004, which then increased to 38% in 2005 (P
Original languageEnglish
Pages (from-to)58-63
JournalInternational Journal of Antimicrobial Agents
Issue number1
Publication statusPublished - 1 Jan 2008

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