Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections – A Multinational Study

Nina Lindfors, Jan Geurts, Lorenzo Drago, J. J. Arts, Vesa Juutilainen, Pekka Hyvönen, Arnold J. Suda, Aloj Domenico, Stefano Artiaco, Chingiz Alizadeh, Adrian Brychcy, Jertzy Bialecki, Carlo L. Romanò

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitute with proven antibacterial and bone bonding properties.

One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital.

The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15–87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12–95 months, median 31).

The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery.

The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.
Original languageEnglish
Title of host publicationA Modern Approach to Biofilm-Related Orthopaedic Implant Infections
Subtitle of host publicationAdvances in Microbiology, Infectious Diseases and Public Health Volume 5
EditorsL Drago
PublisherSpringer
Chapter156
Pages81-92
Number of pages12
Volume971
ISBN (Electronic)978-3-319-52274-6
ISBN (Print)978-3-319-52273-9
DOIs
Publication statusPublished - 4 Jan 2017

Publication series

SeriesAdvances in Experimental Medicine and Biology
Volume971
ISSN0065-2598

Keywords

  • Bioactive glass
  • S53P4
  • Osteomyelitis
  • Antibacterial
  • Bone substitute
  • TIBIAL PLATEAU FRACTURES
  • AUTOGENOUS BONE
  • GRAFT SUBSTITUTES
  • OSTEOMYELITIS
  • SPONDYLODESIS
  • OBLITERATION
  • GRANULES

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