One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital.
The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15–87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12–95 months, median 31).
The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery.
The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.
|Title of host publication||A Modern Approach to Biofilm-Related Orthopaedic Implant Infections|
|Subtitle of host publication||Advances in Microbiology, Infectious Diseases and Public Health Volume 5|
|Number of pages||12|
|Publication status||Published - 4 Jan 2017|
|Series||Advances in Experimental Medicine and Biology|
- Bioactive glass
- Bone substitute
- TIBIAL PLATEAU FRACTURES
- AUTOGENOUS BONE
- GRAFT SUBSTITUTES