Aneuploidy in human preimplantation embryos

Joseph P.M. Geraedts*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Even when conditions are optimal, the chance of a clinically recognized pregnancy occurring in a given menstrual cycle is much less than half. Besides failure of conception pre-clinical pregnancy loss is a major cause for the low fecundity observed in humans. Chromosome abnormalities are the predominant cause of this clinical problem, both in natural conceptions as well as after assisted reproduction [21]. About 42 % of all oocytes exposed to natural fertilization survive until after implantation, and only 31 % will lead to a live birth (Fig. 17.1).
Original languageEnglish
Title of host publicationHuman Fetal Growth and Development: First and Second Trimesters
EditorsNiranjan Bhattacharya, Philip G. Stubblefield
PublisherSpringer International Publishing
Pages231-236
Number of pages6
ISBN (Electronic)9783319148748
ISBN (Print)9783319148731
DOIs
Publication statusPublished - 2016

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