@inproceedings{22c8ab5dd24d48e49f39b03403e79819,
title = "Analysis of biomarkers and composite scores in IBD patients using probabilistic fuzzy systems",
abstract = "The incidence of inflammatory bowel disease (IBD) is rising worldwide. Preventing disease progression by tight monitoring of disease activity using non-invasive procedures is important to prevent disease progression. In literature composite scores, combining biomarkers and clinical activity scores, have been described which aim to detect disease activity.In this paper we analyze the components of these composite scores in a data-driven manner using probabilistic fuzzy system (PFS). In this paper, we define a specific PFS for the analysis of the relationship between the biomarker fecal calprotectin (FC), with biomarkers erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and clinical activity scores for two disease phenotypes, namely Crohn's disease and ulcerative colitis.We report the relations between these biomarkers and clinical activity scores using the proposed PFS, and show how the statistical properties of FC indicator relates to the remaining biomarkers and clinical activity scores. Furthermore, we related the findings on the clinical activity scores to the conventional thresholds used in the literature to define susceptibility of disease activity to support clinical interpretation of results. The results show that analyzing the recently available data using PFS lead to valuable information for detecting IBD disease activity where most conventional thresholds for disease indicators are in line with the data-based findings.",
keywords = "Biomarker analysis, probabilistic fuzzy systems, Inflammatory bowel disease, Fecal calprotectin, INFLAMMATORY-BOWEL-DISEASE, FECAL CALPROTECTIN, CROHNS-DISEASE, ENDOSCOPIC SCORE, MANAGEMENT, MARKER",
author = "G.M.C. Adriaans and R.J. Almeida and D. Jonkers and {van den Heuvel}, T. and A.G.L. Bodelier and M.J. Pierik",
note = "data source: Data has been collected between September 2009 and March 2010 by consecutive recruitment of 323 IBD patients who gave informed consent and were visiting the Gastroenterology outpatient clinic in the Maastricht University Medical Center+ in the Netherlands, with approval of the Medical Ethics Committee of the MUMC+. ; IEEE International Conference on Fuzzy Systems, FUZZ-IEEE 2022 ; Conference date: 18-07-2022 Through 23-07-2022",
year = "2022",
doi = "10.1109/FUZZ-IEEE55066.2022.9882584",
language = "English",
isbn = "9781665467100",
series = "IEEE International Fuzzy Systems Conference Proceedings",
publisher = "IEEE",
booktitle = "2022 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE)",
address = "United States",
}